Unrealistic optimism and the ethics of phase I cancer research.
Unrealistic optimism and the ethics of phase I cancer research.
复制标题
DOI：
10.1136/medethics-2012-100752
复制
发表时间：
2013-06
影响因子：
4.1
通讯作者：
Kodish E
中科院分区：
文献类型：
--
作者：
Crites J;Kodish E
第一阶段癌症研究面临的最紧迫的伦理挑战之一集中在知情同意的过程上。从历史上看，大多数学术研究都致力于纠正治疗的误解，即将研究的性质和目标与治疗的性质和目标混为一谈。虽然治疗误解仍然是一个主要的伦理问题，但最近的学术研究已经开始认识到知情同意过程不仅仅是信息的转移，因此不能仅根据个人对此类信息的理解程度进行评估。决策的其他组成部分独立于理解而运作，但仍然可能损害知情同意的质量。在这些因素中值得注意的是不切实际的乐观主义，这是一种针对特定事件的信念，认为一个人比处境相似的其他人有更好的机会获得利益。在本文中，我们考虑了对最近完成了让孩子参加一期癌症临床试验的知情同意会议的家长的采访，以研究这种影响如何表现以及研究人员如何在知情同意期间解决这一问题。
One of the most pressing ethical challenges facing Phase I cancer research centers on the process of informed consent. Historically, most scholarship has been devoted to redressing therapeutic misconception—i.e., the conflation of the nature and goals of research with those of therapy. While therapeutic misconception continues to be a major ethical concern, recent scholarship has begun to recognize that the informed consent process is more complex than merely a transfer of information and therefore cannot be evaluated only according to how well an individual understands such information. Other components of decision making operate independently of understanding and yet still may compromise the quality of informed consent. Notable among these components is unrealistic optimism, an event-specific belief that one has a better chance of receiving benefit than others similarly situated. In this article, we consider responses to interviews with parents who had recently completed an informed consent conference for enrolling their child in a Phase I cancer clinical trial to examine how this influence manifests and how investigators might address it during informed consent.
登录
查看更多内容
影响因子：
6.2
作者：
Sulmasy, Daniel P.;Astrow, Alan B.;He, M. Kai;Seils, Damon M.;Meropol, Neal J.;Micco, Ellyn;Weinfurt, Kevin P.
通讯作者：
Weinfurt, Kevin P.
影响因子：
7.6
作者：
WEINSTEIN, ND
通讯作者：
WEINSTEIN, ND
影响因子：
2.7
作者：
Bergenmar, Mia;Johansson, Hemming;Wilking, Nils
通讯作者：
Wilking, Nils
影响因子：
4.1
作者：
Jansen, Lynn A.
通讯作者：
Jansen, Lynn A.
影响因子：
1.2
作者：
Weinfurt, KP
通讯作者：
Weinfurt, KP