Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study.
Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study.
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辅助生殖技术妊娠的孕产妇和活产结果：一项回顾性队列研究
DOI：
10.1038/srep35141
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发表时间：
2016-10-20
影响因子：
4.6
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Zhu L;Zhang Y;Liu Y;Zhang R;Wu Y;Huang Y;Liu F;Li M;Sun S;Xing L;Zhu Y;Chen Y;Xu L;Zhou L;Huang H;Zhang D
本研究旨在探讨辅助生殖技术（ART）与孕产妇和新生儿结局之间的相关性，并与自然受孕后的类似结局进行比较。我们对2006-2014年期间通过ART妊娠（N = 2641）与自然妊娠（N = 5282）进行了一项回顾性队列研究，匹配了母亲年龄和出生年份。采用多因素Logistic回归分析方法，对入选对象的妊娠并发症、围生儿并发症及新生儿结局进行调查分析。我们发现，体外受精（IVF）妊娠与妊娠期糖尿病、妊娠期高血压、先兆子痫、妊娠肝内胆汁淤积症、前置胎盘、胎盘早剥、早产胎膜早破、胎盘粘连、产后出血、羊水过多、早产、低出生体重、与自然受孕的婴儿相比，通过卵胞浆内单精子注射（ICSI）受孕的妊娠显示出类似的并发症增加，除了一些差异缩小或消失。抗逆转录病毒疗法后的单胎妊娠或未经产妊娠仍然显示出产妇和新生儿并发症增加。因此，我们的结论是，怀孕后的ART是在产前并发症，围产期并发症和不良的新生儿结局的风险增加，这可能是由于不仅多胎妊娠的发生率较高，但也涉及ART过程中的操作。
This study was carried out to explore associations between assisted reproductive technology (ART) and maternal and neonatal outcomes compared with similar outcomes following spontaneously conceived births. We conducted a retrospective cohort study of pregnancies conceived by ART (N = 2641) during 2006–2014 compared to naturally conceived pregnancies (N = 5282) after matching for maternal age and birth year. Pregnancy complications, perinatal complications and neonatal outcomes of enrolled subjects were investigated and analysed by multivariate logistic regression. We found that pregnancies conceived byin vitrofertilization (IVF) were associated with a significantly increased incidence of gestational diabetes mellitus, gestational hypertension, preeclampsia, intrahepatic cholestasis of pregnancy, placenta previa, placental abruption, preterm premature rupture of membranes, placental adherence, postpartum haemorrhage, polyhydramnios, preterm labour, low birth weight, and small-for-date infant compared with spontaneously conceived births. Pregnancies conceived by intracytoplasmic sperm injection (ICSI) showed similar elevated complications, except some of the difference narrowed or disappeared. Singleton pregnancies or nulliparous pregnancies following ART still exhibited increased maternal and neonatal complications. Therefore, we conclude that pregnancies conceived following ART are at increased risks of antenatal complications, perinatal complications and poor neonatal outcomes, which may result from not only a higher incidence of multiple pregnancy, but also the manipulation involved in ART processes.
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影响因子：
7.2
作者：
Jackson, RA;Gibson, KA;Croughan, MS
通讯作者：
Croughan, MS
DOI：
10.1016/s1701-2163(16)32862-6
发表时间：
2008-06-01
影响因子：
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作者：
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通讯作者：
von Dadelszen, Peter
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1.5
作者：
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作者：
Li, T;Vu, TH;Hoffman, AR
通讯作者：
Hoffman, AR
DOI：
10.1016/j.bpobgyn.2013.11.005
发表时间：
2014-02-01
影响因子：
5.5
作者：
Bhattacharya, Siladitya;Kamath, Mohan S.
通讯作者：
Kamath, Mohan S.