Natural Killer Cells in Human Immunodeficiency Virus-1 Infection: Spotlight on the Impact of Human Cytomegalovirus.
Natural Killer Cells in Human Immunodeficiency Virus-1 Infection: Spotlight on the Impact of Human Cytomegalovirus.
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DOI：
10.3389/fimmu.2017.01322
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发表时间：
2017
影响因子：
7.3
通讯作者：
Peppa D
中科院分区：
文献类型：
--
作者：
Peppa D
人类巨细胞病毒（HCMV）与人类在进化过程中密切相关。HCMV合并感染在人类免疫缺陷病毒-1（HIV-1）感染者中几乎是普遍的，即使在有效的抗逆转录病毒治疗的时代，HCMV合并感染仍然是HIV-1疾病进展的重要辅助因素。HCMV感染已被证明对人类免疫系统具有广泛而有力的影响，并与适应性自然杀伤（NK）细胞的发现和表征有关。不同的NK细胞亚群，主要表达活化受体NKG 2C和终末分化标志物CD 57，响应HCMV而扩增。除了表面受体的特征性但可变的表达外，这些参与与HCMV的持久相互作用的NK细胞群体还表现出典型NK细胞表达的信号蛋白和转录因子的表达降低。广泛的表观遗传修饰驱动具有不同功能特征的HCMV适应性NK细胞的出现和持续存在。在HIV-1感染患者和其他急性和慢性病毒感染患者中观察到NKG 2C + NK细胞扩增，与HCMV血清阳性系统相关。后者可能是一个重要的混杂变量的研究集中在细胞NK细胞受体库和功能能力。在这里，我们集中在HIV-1感染的证据，有利于“适应性”的变化可能引起的HCMV共感染的NK细胞亚群。我们强调了一些关键问题，以及对NK细胞适应性行为的见解将如何为利用其独特特性对抗HIV-1的新策略提供信息。
Human cytomegalovirus (HCMV) has been closely associated with the human race across evolutionary time. HCMV co-infection is nearly universal in human immunodeficiency virus-1 (HIV-1)-infected individuals and remains an important cofactor in HIV-1 disease progression even in the era of effective antiretroviral treatment. HCMV infection has been shown to have a broad and potent influence on the human immune system and has been linked with the discovery and characterization of adaptive natural killer (NK) cells. Distinct NK-cell subsets, predominately expressing the activating receptor NKG2C and the marker of terminal differentiation CD57, expand in response to HCMV. These NK-cell populations engaged in the long-lasting interaction with HCMV, in addition to characteristic but variable expression of surface receptors, exhibit reduced expression of signaling proteins and transcription factors expressed by canonical NK cells. Broad epigenetic modifications drive the emergence and persistence of HCMV-adapted NK cells that have distinct functional characteristics. NKG2C+ NK-cell expansions have been observed in HIV-1 infected patients and other acute and chronic viral infections being systematically associated with HCMV seropositivity. The latter is potentially an important confounding variable in studies focused on the cellular NK-cell receptor repertoire and functional capacity. Here, focusing on HIV-1 infection we review the evidence in favor of “adaptive” changes likely induced by HCMV co-infection in NK-cell subsets. We highlight a number of key questions and how insights into the adaptive behavior of NK cells will inform new strategies exploiting their unique properties in the fight against HIV-1.
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影响因子：
64.5
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
通讯作者：
Davis MM
影响因子：
3.8
作者：
Boulet, Salix;Sharafi, Saeid;Bernard, Nicole F.
通讯作者：
Bernard, Nicole F.
影响因子：
3.4
作者：
Emery, VC
通讯作者：
Emery, VC
影响因子：
5.4
作者：
Darboe, Alansana;Danso, Ebrima;Goodier, Martin R.
通讯作者：
Goodier, Martin R.
DOI：
10.1186/s12979-015-0041-0
发表时间：
2015
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Affandi JS;Montgomery J;Brunt SJ;Nolan D;Price P
通讯作者：
Price P