The conjugacy of the vestibulo-ocular reflex evoked by single labyrinth stimulation in awake monkeys.
The conjugacy of the vestibulo-ocular reflex evoked by single labyrinth stimulation in awake monkeys.
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DOI：
10.1007/s00221-010-2403-3
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发表时间：
2010-10
影响因子：
2
通讯作者：
Zhou, Wu
中科院分区：
文献类型：
--
作者：
Tang, Xuehui;Xu, Youguo;Simpson, Ivra;Jeffcoat, Ben;Mustain, William;Zhou, Wu
众所周知，前庭-眼反射(VOR)在黑暗中测量时是共轭的，具有最小的聚光。但VOR共轭的神经基础仍有待确定。在本研究中，我们测量了单个迷路刺激时的VOR共轭，以检验VOR共轭是否依赖于对两个迷路的相互刺激。在这个问题上存在着相互矛盾的观点。首先，由于Deiters‘s上行束携带的前庭信号仅分布于同侧眼的运动神经元，单迷路刺激后双眼的神经支配不对称。因此，单个迷路刺激可能会产生分离的VOR反应。其次，关于这一问题唯一发表的研究是一项眼电图学(EOG)研究，该研究报告了单侧热量灌溉时的分离VOR反应(Wolfe in Ann Otol 88：79-85,1979)。第三，在临床前庭测试中，单侧热量刺激时的VOR通常被认为是共轭的。为了解决这些相互矛盾的观点，本研究通过使用搜索线圈技术记录清醒猴子的双眼位置信号，研究了单次迷路刺激时的VOR共轭。与以往的EOG研究和基于单侧脑干VOR回路不对称性的预测相反，我们发现单侧能量灌流时的VOR在很大范围内是共轭的。我们的结论是，单眼迷路刺激后，双眼所接受的神经支配是对称的，尽管单侧VOR通路存在明显的不对称性。提出了Deiters上升束在VOR共轭中的新作用。
It is well known that the vestibulo-ocular reflex (VOR) is conjugate when measured in the dark with minimal vergence. But the neural basis of the VOR conjugacy remains to be identified. In the present study, we measured the VOR conjugacy during single labyrinth stimulation to examine whether the VOR conjugacy depends on reciprocal stimulation of the two labyrinths. There are conflicting views on this issue. First, since the vestibular signals carried by the ascending tract of Deiters' are distributed exclusively to the motoneurons of the ipsilateral eye, the neural innervations after single labyrinth stimulation are not symmetrical for the two eyes. Thus, single labyrinth stimulation may generate disjunctive VOR responses. Second, the only published study on this issue was an electrooculography (EOG) study that reported disjunctive VOR responses during unilateral caloric irrigation (Wolfe in Ann Otol 88:79–85, 1979). Third, the VOR during unilateral caloric stimulation performed in clinical vestibular tests is routinely perceived to be conjugate. To resolve these conflicting views, the present study examined the VOR conjugacy during single labyrinth stimulation by recording binocular eye position signals in awake monkeys with a search coil technique. In contradiction to the previous EOG study and the prediction based on the asymmetry of the unilateral brainstem VOR circuits, we found that the VOR during unilateral caloric irrigation was conjugate over a wide range of conditions. We conclude that the net neural innervations received by the two eyes are symmetrical after single labyrinth stimulation, despite the apparent asymmetry in the unilateral VOR pathways. A novel role for the ascending tract of Deiters' in the VOR conjugacy is proposed.
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影响因子：
2
作者：
Khojasteh, Elham;Galiana, Henrietta L.
通讯作者：
Galiana, Henrietta L.
DOI：
10.1007/s10162-009-0178-7
发表时间：
2009-12-01
影响因子：
2.4
作者：
Xu, Youguo;Simpson, Ivra;Zhou, Wu
通讯作者：
Zhou, Wu
影响因子：
2.5
作者：
Arai, Y;Yakushin, SB;Raphan, T
通讯作者：
Raphan, T
影响因子：
1.9
作者：
VILIS, T;TWEED, D
通讯作者：
TWEED, D
影响因子：
2.5
作者：
Zhou, Wu;Xu, Youguo;Cai, Yidao
通讯作者：
Cai, Yidao