Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates.
Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates.
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通过辅助生殖技术怀孕与新生儿端粒长度较短有关。
DOI：
10.3390/ijms21249688
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发表时间：
2020-12-18
影响因子：
5.6
通讯作者：
Kyo S
中科院分区：
文献类型：
--
作者：
Minamoto T;Nakayama K;Ishibashi T;Ishikawa M;Nakamura K;Yamashita H;Shanta K;Mahmud HM;Razia S;Iida K;Sakashita G;Nakamura T;Kanda H;Kyo S
端粒长度（TL）影响生活方式相关疾病的发展，而新生儿端粒长度可能影响其患病率。据报道，各种因素影响新生儿TL。虽然胎儿在子宫内暴露于多种条件下，但影响新生儿TL缩短的主要因素仍不清楚。在这项研究中，我们试图确定影响胎儿TL的因素。共有578对母亲-新生儿被纳入TL分析。使用定量PCR从脐带血样品提取的基因组DNA中测量TL。入组时检查的临床因素包括以下宫内环境因素：母亲年龄、使用的辅助生殖技术（ART）、体重指数（BMI）、妊娠期糖尿病（GDM）、母亲压力、吸烟、饮酒、早产、小于胎龄儿、新生儿性别和胎盘重量。采用单因素和多因素回归分析验证新生儿TL与这些临床因素的关系。中位新生儿TL与单拷贝基因比率为1.0。妊娠合并ART是与新生儿TL较短相关的11个因素之一。通过多元回归分析，我们确定ART组的新生儿TL明显短于其他组。我们的结论是，妊娠与ART是与较短的新生儿TL。
Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not known. In this study, we sought to identify factors that influence fetal TL. A total of 578 mother-newborn pairs were included for TL analysis. TL was measured in genomic DNA extracted from cord blood samples using quantitative PCR. The clinical factors examined at enrollment included the following intrauterine environmental factors: maternal age, assisted reproductive technology (ART) used, body mass index (BMI), gestational diabetes mellitus (GDM), maternal stress, smoking, alcohol consumption, preterm delivery, small-for-gestational-age, neonatal sex, and placental weight. Univariate and multivariate regression analyses were used to verify the relationship between neonatal TL and these clinical factors. The median neonatal TL to single-copy gene ratio was 1.0. Pregnancy with ART was among the 11 factors associated with shorter neonatal TL. From multiple regression analysis, we determined that neonatal TL was significantly shorter for pregnancies in the ART group than in the other groups. We conclude that pregnancy with ART is associated with shorter neonatal TL.
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DOI：
10.1186/1477-7827-10-49
发表时间：
2012-06-29
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Agarwal A;Aponte-Mellado A;Premkumar BJ;Shaman A;Gupta S
通讯作者：
Gupta S
影响因子：
9.8
作者：
Marchetto, Nicole M.;Glynn, Rebecca A.;Haussmann, Mark F.
通讯作者：
Haussmann, Mark F.
DOI：
10.1136/bmj.g4227
发表时间：
2014-07-08
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Haycock PC;Heydon EE;Kaptoge S;Butterworth AS;Thompson A;Willeit P
通讯作者：
Willeit P
影响因子：
9.8
作者：
Entringer, Sonja;Epel, Elissa S.;Lin, Jue;Buss, Claudia;Shahbaba, Babak;Blackburn, Elizabeth H.;Simhan, Hyagriv N.;Wadhwa, Pathik D.
通讯作者：
Wadhwa, Pathik D.
影响因子：
--
作者：
Mazidi M;Rezaie P;Covic A;Malyszko J;Rysz J;Kengne AP;Banach M
通讯作者：
Banach M