The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum.
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum.
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DOI：
10.1038/ng.2373
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发表时间：
2012-09
期刊：
影响因子：
30.8
通讯作者：
Carlton, Jane M.
中科院分区：
文献类型：
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作者：
Neafsey, Daniel E.;Galinsky, Kevin;Jiang, Rays H. Y.;Young, Lauren;Sykes, Sean M.;Saif, Sakina;Gujja, Sharvari;Goldberg, Jonathan M.;Young, Sarah;Zeng, Qiandong;Chapman, Sinead B.;Dash, Aditya P.;Anvikar, Anupkumar R.;Sutton, Patrick L.;Birren, Bruce W.;Escalante, Ananias A.;Barnwell, John W.;Carlton, Jane M.
我们对从不同地理位置收集的四种间日疟原虫株的基因组进行了测序和注释，使这种未充分研究的寄生虫的基因组序列数量增加了两倍，并提供了该物种内全球变异性的第一个全基因组视角。我们在这些分离株中观察到的SNP多样性大约是恶性疟原虫分离株的两倍，恶性疟原虫是一种导致更高死亡率的疟疾寄生虫。这表明间日疟原虫的全球定殖历史和/或比恶性疟原虫更稳定的人口统计学历史，恶性疟原虫被认为最近经历了人口瓶颈。SNP多样性以及额外的微卫星和基因家族变异性表明，间日疟原虫全球种群内具有更大的功能变异能力。这些发现证明需要对间日疟原虫的变异进行更深入的调查，以针对这种被忽视但主要的病原体的独特生物学进行疾病干预。
We sequenced and annotated the genomes of four Plasmodium vivax strains collected from disparate geographical locations, tripling the number of genome sequences available for this understudied parasite and providing the first genome-wide perspective of global variability within this species. We observe approximately twice as much SNP diversity among these isolates as we do among a comparable collection of isolates of Plasmodium falciparum, a malaria parasite that causes higher mortality. This indicates a distinct history of global colonization and/or a more stable demographic history for P. vivax than P. falciparum, which is thought to have undergone a recent population bottleneck. The SNP diversity, as well as additional microsatellite and gene family variability, suggests the capacity for greater functional variation within the global population of P. vivax. These findings warrant a deeper survey of variation in P. vivax to equip disease interventions targeting the distinctive biology of this neglected but major pathogen.
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影响因子：
64.8
作者：
Carlton, Jane M.;Adams, John H.;Silva, Joana C.;Bidwell, Shelby L.;Lorenzi, Hernan;Caler, Elisabet;Crabtree, Jonathan;Angiuoli, Samuel V.;Merino, Emilio F.;Amedeo, Paolo;Cheng, Qin;Coulson, Richard M. R.;Crabb, Brendan S.;del Portillo, Hernando A.;Essien, Kobby;Feldblyum, Tamara V.;Fernandez-Becerra, Carmen;Gilson, Paul R.;Gueye, Amy H.;Guo, Xiang;Kang'a, Simon;Kooij, Taco W. A.;Korsinczky, Michael;Meyer, Esmeralda V. -S.;Nene, Vish;Paulsen, Ian;White, Owen;Ralph, Stuart A.;Ren, Qinghu;Sargeant, Tobias J.;Salzberg, Steven L.;Stoeckert, Christian J.;Sullivan, Steven A.;Yamamoto, Marcio M.;Hoffman, Stephen L.;Wortman, Jennifer R.;Gardner, Malcolm J.;Galinski, Mary R.;Barnwell, John W.;Fraser-Liggett, Claire M.
通讯作者：
Fraser-Liggett, Claire M.
影响因子：
3.8
作者：
Carlton JM;Sina BJ;Adams JH
通讯作者：
Adams JH
影响因子：
--
作者：
Griffiths-Jones, Sam
通讯作者：
Griffiths-Jones, Sam
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Lagesen K;Hallin P;Rødland EA;Staerfeldt HH;Rognes T;Ussery DW
通讯作者：
Ussery DW