Maternal and cord blood 25(OH)-vitamin D concentrations in relation to child development and behaviour.
Maternal and cord blood 25(OH)-vitamin D concentrations in relation to child development and behaviour.
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DOI：
10.1111/ppe.12135
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发表时间：
2014-09
影响因子：
2.8
通讯作者：
Klebanoff MA
中科院分区：
文献类型：
--
作者：
Keim SA;Bodnar LM;Klebanoff MA
Animal studies have linked in utero vitamin D exposure to various aspects of offspring brain development. Limited research has translated these findings to humans, and none have employed cord blood to measure exposure late in gestation. Our objective was to examine associations between maternal 25(OH)D measured at ≤26 weeks’ gestation or cord blood 25(OH)D and offspring global development, IQ, achievement, and behavior in the U.S. Collaborative Perinatal Project (1959–73). This was a secondary analysis of data from a case-cohort study, with 3896 women and children who participated in at least one outcome assessment. Psychologists assessed global development at eight months, IQ and behavior at four and seven years, and achievement at seven years. Multiple linear and logistic regression was used to examine associations between 25(OH)D and child outcomes, controlling for maternal education, age, parity, race, maternal BMI, marital status, smoking, gestational age and month of blood draw, and study site. Positive associations for many outcomes were greatly attenuated upon adjustment for confounders and were generally null. Only IQ at age 7 was associated with both maternal and cord blood 25(OH)D, but the effect estimates were very small (β for 5 nmol/L increment of maternal 25(OH)D=0.10; 95% CI: 0.00, 0.19). We observed very little indication that maternal or cord blood 25(OH)D are associated with cognitive development, achievement and behavior between 8 months and 7 years of age.
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影响因子：
4.2
作者：
Kubzansky, LD;Martin, LT;Buka, SL
通讯作者：
Buka, SL
影响因子：
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作者：
Javaid, MK;Crozier, SR;Cooper, C
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Cooper, C
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Kesby, James P.;Burne, Thomas H. J.;Eyles, Darryl W.
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Eyles, Darryl W.
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Marini, Francesca;Bartoccini, Elisa;Albi, Elisabetta
通讯作者：
Albi, Elisabetta
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4.7
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Gale, C. R.;Robinson, S. M.;Harvey, N. C.;Javaid, M. K.;Jiang, B.;Martyn, C. N.;Godfrey, K. M.;Cooper, C.
通讯作者：
Cooper, C.