Maternal vitamin D status during pregnancy and child outcomes.
Maternal vitamin D status during pregnancy and child outcomes.
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DOI：
10.1038/sj.ejcn.1602680
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发表时间：
2008-01
影响因子：
4.7
通讯作者：
Cooper, C.
中科院分区：
文献类型：
--
作者：
Gale, C. R.;Robinson, S. M.;Harvey, N. C.;Javaid, M. K.;Jiang, B.;Martyn, C. N.;Godfrey, K. M.;Cooper, C.
研究孕妇暴露于高浓度的25（OH）-维生素D是否会对儿童造成任何风险。前瞻性研究。英国南安普顿安妮公主妇产医院。共招募了596名孕妇。466名（78%）儿童在出生时接受检查，440名（74%）在9个月大时接受检查，178名（30%）在9岁时接受检查。母亲（OH）-维生素D浓度在怀孕后期进行了测量。在出生、9个月和9岁时记录儿童的人体测量。在9个月时，评估特应性湿疹。9岁时，儿童进行超声心动图和DXA扫描，测量血压、动脉顺应性和颈动脉内膜中层厚度，并评估智力和心理功能。母亲的25（OH）-维生素D浓度与孩子的体型或孩子的智力，心理健康或心血管系统的测量之间没有关联。母亲在怀孕期间25（OH）-维生素D浓度>75 nmol/l的儿童在9个月时检查时患湿疹的风险增加（OR 3.26，95% CI 1.15-9.29，p=0.025）和9岁时的哮喘（OR 5.40，95% CI，1.09-26.65，p=0.038）与母亲浓度<30 nmol/l的儿童相比。妊娠期暴露于母体25（OH）-维生素D浓度超过75 nmol/l似乎不会影响儿童的智力，心理健康或心血管系统;可能会增加特应性疾病的风险，但这需要在其他研究中证实。
To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child. Prospective study. Princess Anne Maternity Hospital, Southampton, UK. 596 pregnant women were recruited. 466 (78%) children were examined at birth, 440 (74%) at age 9 months and 178 (30%) at age 9 years. Maternal (OH)-vitamin D concentrations were measured in late pregnancy. Anthropometry of the child was recorded at birth, 9 months and 9 years. At 9 months, atopic eczema was assessed. At 9 years, children had an echocardiogram and a DXA scan, blood pressure, arterial compliance and carotid intima-media thickness were measured and intelligence and psychological function assessed. There were no associations between maternal 25(OH)-vitamin D concentrations and the child's body size or measures of the child's intelligence, psychological health or cardiovascular system. Children whose mothers' concentration of 25(OH)-vitamin D in pregnancy was >75 nmol/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15-9.29, p=0.025) and asthma at age 9 years (OR 5.40, 95% CI, 1.09-26.65, p=0.038) compared to children whose mothers' concentration was <30 nmol/l. Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.
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影响因子：
10.8
作者：
Norman, P;Moss, I;Powell, J
通讯作者：
Powell, J
DOI：
10.1196/annals.1337.013
发表时间：
2004-01-01
期刊：
IMMUNOLOGY OF DIABETES III
影响因子：
--
作者：
Hyppönen, E;Sovio, U;Järvelin, MR
通讯作者：
Järvelin, MR
影响因子：
168.9
作者：
Javaid, MK;Crozier, SR;Cooper, C
通讯作者：
Cooper, C
影响因子：
7.1
作者：
Nesby-O'Dell, S;Scanlon, KS;Bowman, BA
通讯作者：
Bowman, BA
影响因子：
105.7
作者：
BROOKE, OG;BROWN, IRF;WINDER, SM
通讯作者：
WINDER, SM