Microstructural dynamics of motor learning and sleep-dependent consolidation: A diffusion imaging study.
Microstructural dynamics of motor learning and sleep-dependent consolidation: A diffusion imaging study.
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运动学习和睡眠依赖性巩固的微结构动力学：扩散成像研究。
DOI：
10.1016/j.isci.2023.108426
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发表时间：
2023-12-15
期刊：
影响因子：
5.8
通讯作者：
Peigneux, Philippe
中科院分区：
文献类型：
--
作者：
Stee, Whitney;Legouhy, Antoine;Guerreri, Michele;Villemonteix, Thomas;Zhang, Hui;Peigneux, Philippe
记忆巩固可以从学习后的睡眠中受益，最终导致长期的微结构大脑修改，以适应新的记忆表征。非侵入性弥散加权磁共振成像（DWI）可以观察限时运动学习后的（微）结构脑重塑。在这里，我们结合联合收割机传统的扩散张量成像（DTI）和神经突方向弥散和密度成像（NODDI），使建模树突和轴突的复杂性，在灰质调查与改善特异性的微观结构的大脑机制的时间和睡眠依赖性运动记忆巩固动态。61名年轻健康的成年人接受了四次DWI会议，两次连续的运动训练，以及一晚的总睡眠剥夺或定期睡眠分布在五天内。我们观察到快速运动学习相关的重塑枕顶，颞叶和运动相关的皮质下区域，反映了学习相关的神经元脑可塑性过程的临时动力学。睡眠相关的巩固似乎没有发挥可检测的影响扩散参数，至少在几天的时间尺度。快速脑组织重塑是对连续运动（再）学习的反应学习相关的变化大多是短暂的，持续时间有限超过3天微结构脑变化不受学习后睡眠可用性的调节NODDI结合DTI方法改善了潜在细胞过程的规范神经科学;细胞神经科学;认知神经科学;神经科学技术
Memory consolidation can benefit from post-learning sleep, eventually leading to long-term microstructural brain modifications to accommodate new memory representations. Non-invasive diffusion-weighted magnetic resonance imaging (DWI) allows the observation of (micro)structural brain remodeling after time-limited motor learning. Here, we combine conventional diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) that allows modeling dendritic and axonal complexity in gray matter to investigate with improved specificity the microstructural brain mechanisms underlying time- and sleep-dependent motor memory consolidation dynamics. Sixty-one young healthy adults underwent four DWI sessions, two sequential motor trainings, and a night of total sleep deprivation or regular sleep distributed over five days. We observed rapid-motor-learning-related remodeling in occipitoparietal, temporal, and motor-related subcortical regions, reflecting temporary dynamics in learning-related neuronal brain plasticity processes. Sleep-related consolidation seems not to exert a detectable impact on diffusion parameters, at least on the timescale of a few days. Rapid brain tissue remodeling arises in response to sequential motor (re)learning Learning-related changes are mostly transient with limited persistence over 3 days Microstructural brain changes are not modulated by post-learning sleep availability NODDI combined with DTI methods improve specification of underlying cellular processes Neuroscience; Cellular neuroscience; Cognitive neuroscience; Techniques in neuroscience
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