Changes in gray matter induced by learning--revisited.
Changes in gray matter induced by learning--revisited.
复制标题
DOI：
10.1371/journal.pone.0002669
复制
发表时间：
2008-07-23
期刊：
影响因子：
3.7
通讯作者：
May A
中科院分区：
文献类型：
--
作者：
Driemeyer J;Boyke J;Gaser C;Büchel C;May A
最近，在成人中，经过三个月的运动技能训练后，人类的激活依赖性结构大脑可塑性已经得到证实。学习三球级联杂耍与包括双侧运动敏感区hMT/V5的枕颞皮质中的脑灰质的短暂和高度选择性增加相关。然而，使用依赖的结构变化发生的确切时间尺度仍然是未知的。更好地理解时间参数可能有助于阐明这种类型的皮质可塑性在多大程度上有助于快速适应可能与学习相关的皮质过程。使用3特斯拉扫描仪和监测整个大脑结构，我们在20名健康成年志愿者中重复并扩展了我们最初的研究，重点关注结构变化的时间方面，并调查这些变化是否依赖于性能或运动。这些数据证实了我们早期使用平均效应分析的观察结果，此外还表明，学习杂耍可以在训练7天后改变枕颞皮层的灰质。无论是表现还是锻炼都不能单独解释这些变化。我们认为，质的变化（即学习一个新的任务）是更重要的大脑改变其结构比继续训练一个已经学会的任务。
Recently, activation-dependant structural brain plasticity in humans has been demonstrated in adults after three months of training a visio-motor skill. Learning three-ball cascade juggling was associated with a transient and highly selective increase in brain gray matter in the occipito-temporal cortex comprising the motion sensitive area hMT/V5 bilaterally. However, the exact time-scale of usage-dependant structural changes occur is still unknown. A better understanding of the temporal parameters may help to elucidate to what extent this type of cortical plasticity contributes to fast adapting cortical processes that may be relevant to learning. Using a 3 Tesla scanner and monitoring whole brain structure we repeated and extended our original study in 20 healthy adult volunteers, focussing on the temporal aspects of the structural changes and investigated whether these changes are performance or exercise dependant. The data confirmed our earlier observation using a mean effects analysis and in addition showed that learning to juggle can alter gray matter in the occipito-temporal cortex as early as after 7 days of training. Neither performance nor exercise alone could explain these changes. We suggest that the qualitative change (i.e. learning of a new task) is more critical for the brain to change its structure than continued training of an already-learned task.
登录
查看更多内容
影响因子：
5.7
作者：
Etgen, T;Draganski, B;May, A
通讯作者：
May, A
影响因子：
6.2
作者：
ANDERSON, BJ;LI, XC;GREENOUGH, WT
通讯作者：
GREENOUGH, WT
影响因子：
64.8
作者：
Kempermann, G;Kuhn, HG;Gage, FH
通讯作者：
Gage, FH
影响因子：
3.7
作者：
May, A.;Hajak, G.;Eichhammer, P.
通讯作者：
Eichhammer, P.
影响因子：
3.3
作者：
Swain, RA;Harris, AB;Greenough, WT
通讯作者：
Greenough, WT