Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis.
Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis.
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DOI：
10.1111/obr.12643
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Fuemmeler BF
中科院分区：
文献类型：
--
作者：
Sanchez CE;Barry C;Sabhlok A;Russell K;Majors A;Kollins SH;Fuemmeler BF
本综述研究了孕妇孕前超重/肥胖状况与儿童神经发育结局之间关联的证据。系统检索PubMed和PsycInfo数据库，检索2017年4月之前发表的与产前肥胖和儿童神经发育相关的关键词的实证研究。在1483篇被确定的论文中，41篇被纳入系统评价，32篇代表36个队列的文章被纳入meta分析。研究结果表明，与正常体重母亲的孩子相比，怀孕前母亲超重或肥胖的孩子神经发育结果受损的风险增加（超重：or =1.17, 95% CI [1.11, 1.24], I2 = 65.51；肥胖：or =1.51; 95% CI [1.35, 1.69], I2 = 79.63）。孕前肥胖增加了ADHD （OR=1.62; 95% CI [1.23, 2.14], I2 = 70.15）、ASD （OR=1.36; 95% CI [1.08, 1.70], I2 = 60.52）、发育迟缓（OR=1.58; 95% CI [1.39, 1.79], I2 = 75.77）和情绪/行为问题（OR=1.42; 95% CI [1.26, 1.59], I2 = 87.74）的风险。鉴于目前肥胖在年轻人和育龄妇女中的流行，怀孕期间母亲肥胖与非典型儿童神经发育之间的这种关联代表了潜在的高公共卫生负担。
This review examined evidence of the association between maternal pre-pregnancy overweight/obesity status and child neurodevelopmental outcomes. PubMed and PsycInfo databases were systematically searched for empirical studies published before April 2017 using keywords related to prenatal obesity and children’s neurodevelopment. Of 1483 identified papers, 41 were included in the systematic review, and 32 articles representing 36 cohorts were included in the meta-analysis. Findings indicated that compared with children of normal weight mothers, children whose mothers were overweight or obese prior to pregnancy were at increased risk for compromised neurodevelopmental outcomes (overweight: OR=1.17, 95% CI [1.11, 1.24], I2 = 65.51; obese: OR=1.51; 95% CI [1.35, 1.69], I2 = 79.63). Pre-pregnancy obesity increased the risk of ADHD (OR=1.62; 95% CI [1.23, 2.14], I2 = 70.15), ASD (OR=1.36; 95% CI [1.08, 1.70], I2 = 60.52), developmental delay (OR=1.58; 95% CI [1.39, 1.79], I2 = 75.77), and emotional/behavioral problems (OR=1.42; 95% CI [1.26, 1.59], I2 = 87.74). Given the current obesity prevalence among young adults and women of childbearing age, this association between maternal obesity during pregnancy and atypical child neurodevelopment represents a potentially high public health burden.
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