The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.
The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.
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DOI：
10.1038/s41598-022-24394-0
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发表时间：
2022-11-17
影响因子：
4.6
通讯作者：
Ren, Tianying
中科院分区：
文献类型：
--
作者：
He, Wenxuan;Burwood, George;Porsov, Edward, V;Fridberger, Anders;Nuttall, Alfred L.;Ren, Tianying
耳蜗功能的流行理论指出，外毛细胞放大声音引起的振动，以提高听觉灵敏度和频率特异性。最近通过圆窗对沙鼠耳蜗底回的微力学测量表明，网状板的振动滞后于基底膜的振动，不仅在最佳频率下，而且在低频率下，它在生理上是脆弱的。这些结果表明，外毛细胞从一个广泛的耳蜗区域通过一个全球的流体力学机制提高听力灵敏度。然而，网状板和基底膜振动之间的时间差被认为是由光轴不垂直于耳蜗分区引起的系统测量误差引起的。为了解决这个问题，我们测量了网状板和基底膜振动的横向方向通过在耳蜗外侧壁的开口在这项研究中。目前的研究结果表明，之间的相位差的网状板和基底膜振动随频率降低约180度，从低频率到最佳频率，通过圆窗测量一致。通过耳蜗外侧壁的低相干干涉测量与圆窗测量一起表明，网状板和基底膜振动之间的时间差是耳蜗主动处理的结果，而不是测量误差。
The prevailing theory of cochlear function states that outer hair cells amplify sound-induced vibration to improve hearing sensitivity and frequency specificity. Recent micromechanical measurements in the basal turn of gerbil cochleae through the round window have demonstrated that the reticular lamina vibration lags the basilar membrane vibration, and it is physiologically vulnerable not only at the best frequency but also at the low frequencies. These results suggest that outer hair cells from a broad cochlear region enhance hearing sensitivity through a global hydromechanical mechanism. However, the time difference between the reticular lamina and basilar membrane vibration has been thought to result from a systematic measurement error caused by the optical axis non-perpendicular to the cochlear partition. To address this concern, we measured the reticular lamina and basilar membrane vibrations in the transverse direction through an opening in the cochlear lateral wall in this study. Present results show that the phase difference between the reticular lamina and basilar membrane vibration decreases with frequency by ~ 180 degrees from low frequencies to the best frequency, consistent with those measured through the round window. Together with the round-window measurement, the low-coherence interferometry through the cochlear lateral wall demonstrates that the time difference between the reticular lamina and basilar membrane vibration results from the cochlear active processing rather than a measurement error.
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影响因子：
4.6
作者：
通讯作者：
--
影响因子：
16.6
作者：
Nuttall AL;Ricci AJ;Burwood G;Harte JM;Stenfelt S;Cayé-Thomasen P;Ren T;Ramamoorthy S;Zhang Y;Wilson T;Lunner T;Moore BCJ;Fridberger A
通讯作者：
Fridberger A
影响因子：
7.7
作者：
He W;Kemp D;Ren T
通讯作者：
Ren T
影响因子：
2.4
作者：
NUTTALL, AL;DOLAN, DF
通讯作者：
DOLAN, DF
影响因子：
2.8
作者：
He, Wenxuan;Burwood, George;Fridberger, Anders;Nuttall, Alfred L.;Ren, Tianying
通讯作者：
Ren, Tianying