Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation.
Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation.
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环状RNA has_circ_0067934在食管鳞状细胞癌中上调并促进增殖
DOI：
10.1038/srep35576
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发表时间：
2016-10-18
影响因子：
4.6
通讯作者：
Yin R
中科院分区：
文献类型：
--
作者：
Xia W;Qiu M;Chen R;Wang S;Leng X;Wang J;Xu Y;Hu J;Dong G;Xu PL;Yin R
食管鳞状细胞癌（ESCC）是世界范围内最常见、最致命的恶性肿瘤之一，尤其是在东亚地区，其预后一直很差。最近的证据表明，环状RNA（circRNA）在包括癌症在内的多种疾病中发挥重要作用。在这项研究中，我们表征了ESCC肿瘤组织和细胞系中一种名为hsa_circ_0067934的新型circRNA。我们分析了51例患者的队列，发现hsa_circ_0067934在ESCC组织中与配对的相邻正常组织相比显著过表达。hsa_circ_0067934的高表达水平与低分化（P= 0.025）、I-II T分期（P=0.04）和I-II TNM分期（P=0.021）相关。siRNA沉默hsa_circ_0067934可抑制食管鳞癌细胞的增殖和迁移，并阻断细胞周期进程。细胞组分分析和荧光原位杂交检测到hsa_circ_0067934主要定位于细胞质中。我们的研究结果表明hsa_circ_0067934在ESCC肿瘤组织中上调。我们的数据表明，hsa_circ_0067934代表了一种新的潜在的生物标志物和ESCC的治疗靶点。
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent and deadly types of cancer worldwide especially in Eastern Asia and the prognosis of ESCC remain poor. Recent evidence suggests that circular RNAs (circRNAs) play important roles in multiple diseases, including cancer. In this study, we characterized a novel circRNA termed hsa_circ_0067934 in ESCC tumor tissues and cell lines. We analyzed a cohort of 51 patients and found that hsa_circ_0067934 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues. The high expression level of hsa_circ_0067934 was associated with poor differentiation (P= 0.025), I-II T stage (P=0.04), and I-II TNM stage (P=0.021). Thein vitrosilence of hsa_circ_0067934 by siRNA inhibited the proliferation and migration of ESCC cells and blocked cell cycle progression. Cell fraction analyses and fluorescencein situhybridization detected that hsa_circ_0067934 was mostly located in the cytoplasm. Our findings suggest that hsa_circ_0067934 is upregulated in ESCC tumor tissue. Our data suggest that hsa_circ_0067934 represents a novel potential biomarker and therapeutic target of ESCC.
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影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
Sharpless NE
影响因子：
--
作者：
Li F;Zhang L;Li W;Deng J;Zheng J;An M;Lu J;Zhou Y
通讯作者：
Zhou Y
影响因子：
14.9
作者：
Bailleul, B
通讯作者：
Bailleul, B
长非编码RNA PlncRNA-1的上调促进食管鳞癌细胞增殖并与晚期临床分期相关
影响因子：
3.1
作者：
Wang, Chun-Mei;Wu, Qing-Quan;Cao, Xiu-Feng
通讯作者：
Cao, Xiu-Feng
影响因子：
4.5
作者：
Salzman J;Chen RE;Olsen MN;Wang PL;Brown PO
通讯作者：
Brown PO