Preterm Birth Alters the Maturation of the GABAergic System in the Human Prefrontal Cortex.
Preterm Birth Alters the Maturation of the GABAergic System in the Human Prefrontal Cortex.
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DOI：
10.3389/fnmol.2021.827370
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发表时间：
2021
影响因子：
4.8
通讯作者：
Penn AA
中科院分区：
文献类型：
--
作者：
Lacaille H;Vacher CM;Penn AA
Developmental changes in GABAergic and glutamatergic systems during frontal lobe development have been hypothesized to play a key role in neurodevelopmental disorders seen in children born very preterm or at/with low birth weight, but the associated cellular changes have not yet been identified. Here we studied the molecular development of the GABAergic system specifically in the dorsolateral prefrontal cortex, a region that has been implicated in neurodevelopmental and psychiatric disorders. The maturation state of the GABAergic system in this region was assessed in human post-mortem brain samples, from term infants ranging in age from 0 to 8 months (n = 17 male, 9 female). Gene expression was measured for 47 GABAergic genes and used to calculate a maturation index. This maturation index was significantly more dynamic in male than female infants. To evaluate the impact of premature birth on the GABAergic system development, samples from 1-month-old term (n = 9 male, 4 female) and 1-month corrected-age very preterm (n = 8 male, 6 female) infants, were compared using the same gene list and methodology. The maturation index for the GABAergic system was significantly lower (−50%, p < 0.05) in male preterm infants, with major alterations in genes linked to GABAergic function in astrocytes, suggesting astrocytic GABAergic developmental changes as a new cellular mechanism underlying preterm brain injury.
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影响因子：
2.9
作者：
Tomiyasu, Moyoko;Aida, Noriko;Shibasaki, Jun;Umeda, Masahiro;Murata, Katsutoshi;Heberlein, Keith;Brown, Mark A.;Shimizu, Eiji;Tsuji, Hiroshi;Obata, Takayuki
通讯作者：
Obata, Takayuki
影响因子：
16.6
作者：
Batiuk, Mykhailo Y.;Martirosyan, Araks;Holt, Matthew G.
通讯作者：
Holt, Matthew G.
影响因子：
3.4
作者：
Lacaille, Helene;Vacher, Claire-Marie;Penn, Anna A.
通讯作者：
Penn, Anna A.
影响因子：
2.5
作者：
Kwon SH;Scheinost D;Lacadie C;Benjamin J;Myers EH;Qiu M;Schneider KC;Rothman DL;Constable RT;Ment LR
通讯作者：
Ment LR
影响因子：
11
作者：
Hashimoto, T.;Arion, D.;Lewis, D. A.
通讯作者：
Lewis, D. A.