GABA, resting-state connectivity and the developing brain.
GABA, resting-state connectivity and the developing brain.
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作者：
Kwon SH;Scheinost D;Lacadie C;Benjamin J;Myers EH;Qiu M;Schneider KC;Rothman DL;Constable RT;Ment LR
临床前数据表明，γ-氨基丁酸（GABA）中间神经元在发育中的大脑中启动连接。本研究的目的是比较GABA浓度及其与足月和早产儿大脑功能连接的关系。婴儿同时接受MRS和功能磁共振成像扫描，在长期等效的年龄。比较使用内在连接分布（ICD）图的全脑功能连接MRI数据，以确定早产儿和足月对照组之间静息状态功能连接差异的区域。磁共振波谱测量GABA、谷氨酸、N-乙酰天冬氨酸（NAA）和胆碱的浓度，并计算NAA/胆碱，以比较两组之间的差异。早产儿右额叶GABA和谷氨酸浓度低于足月对照组，并且右额叶的连接性和GABA浓度之间存在显著不同的关系。早产儿GABA浓度和连接之间呈正相关，而长期控制表现出这两个发育调节参数之间的负相关。这些结果表明，区域GABA浓度与正常和改变新生儿静息状态连接。
Preclinical data demonstrate that gamma-aminobutyric acid (GABA) interneurons initiate connectivity in the developing brain. The goal of this study was to compare GABA concentration and its relationship to functional connectivity in the brains of term and preterm infants at term equivalent age. Infants received both MRS and fMRI scans at term equivalent age. Whole brain functional connectivity MRI data using intrinsic connectivity distribution (ICD) maps were compared to identify areas with differences in resting state functional connectivity between the preterm and term control groups. MR spectroscopy measured concentrations of GABA, glutamate, N-acetyl-aspartate (NAA) and choline, and NAA/choline was calculated for comparison between the two groups. Preterm infants had lower right frontal GABA and glutamate concentrations than term controls and showed a significantly different relationship between connectivity and GABA concentration in the right frontal lobe. Preterm infants had a positive correlation between GABA concentration and connectivity, while term controls demonstrated a negative correlation between these two developmentally-regulated parameters. These results suggest that regional GABA concentrations are associated with normal and altered neonatal resting state connectivity.
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早产婴儿的脑损伤：破坏性和发育障碍的复杂汞合金。
影响因子：
48
作者：
Volpe, Joseph J.
通讯作者：
Volpe, Joseph J.
影响因子：
3
作者：
Joshi A;Scheinost D;Okuda H;Belhachemi D;Murphy I;Staib LH;Papademetris X
通讯作者：
Papademetris X
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo
DOI：
10.1073/pnas.0900728106
发表时间：
2009-05-19
影响因子：
11.1
作者：
Muthukumaraswamy, Suresh D.;Edden, Richard A. E.;Singh, Krish D.
通讯作者：
Singh, Krish D.
影响因子：
--
作者：
Stagg, Charlotte J;Bachtiar, Velicia;Johansen-Berg, Heidi
通讯作者：
Johansen-Berg, Heidi