Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning.
Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning.
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DOI：
10.1111/nyas.14347
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发表时间：
2020-11
影响因子：
5.2
通讯作者：
McCranor BJ
中科院分区：
文献类型：
--
作者：
DeLey Cox VE;Hartog MA;Pueblo E;Racine M;Jennings L;Tressler J;Tuet WY;Stone S;Pierce SA;Thompson L;Dukes A;Hoard-Fruchey H;Wong B;McCranor BJ
氟乙酸盐（FA）是一种无味、无臭、水溶性代谢毒物，具有严重的毒理作用。它出现于 20 世纪 20 年代中期，曾被用作灭鼠剂，但对所有哺乳动物都具有相当的致命性。许多国家都限制其使用，现代人体意外接触的情况很少见，但最近，人们对其作为化学武器的应用表示担忧，且没有已知的解毒剂。建议将亚甲蓝（MB）（一种抗氧化剂）和谷氨酸钠（MSG）（柠檬酸循环底物α-酮戊二酸的前体）联合治疗，作为有效的对策；然而，尚未发表任何同行评审的文章来记录这种疗法的功效。使用啮齿动物模型，我们评估了 MB 和 MSG 对神经系统、心脏和肺系统的影响。转录组分析用于阐明炎症通路激活并指导生物测定，揭示了这些候选对策的优点和缺点。结果表明，MB 和 MSG 可以减少暴露于 FA 钠的大鼠中观察到的神经体征，并改善中毒的一些影响。然而，虽然这一策略解决了一些中毒迹象，但最终无法显着降低致死率。使用啮齿动物模型，我们评估了亚甲蓝 (MB) 和谷氨酸钠 (MSG) 对神经系统、心脏和肺系统的影响。结果表明，MB 和 MSG 可以减少暴露于氟乙酸钠的大鼠中观察到的神经体征，并改善中毒的一些影响。然而，虽然这一策略解决了一些中毒迹象，但最终无法显着降低致死率。
Fluoroacetate (FA) is a tasteless, odorless, water-soluble metabolic poison with severe toxicological effects. Characterized in the mid-1900s, it has been used as a rodenticide but is comparably lethal to all mammals. Many countries have restricted its use, and modern-day accidental human exposures are rare, but recently, concerns have been raised about its application as a chemical weapon with no known antidote. A combined treatment of methylene blue (MB), an antioxidant, and monosodium glutamate (MSG), a precursor of the citric acid cycle substrate alpha-ketoglutarate, has been recommended as an effective countermeasure; however, no peer-reviewed articles documenting the efficacy of this therapy have been published. Using a rodent model, we assessed the effects of MB and MSG on the neurologic, cardiac, and pulmonary systems. Transcriptomic analysis was used to elucidate inflammatory pathway activation and guide bioassays, which revealed the advantages and disadvantages of these candidate countermeasures. Results show MB and MSG can reduce neurologic signs observed in rats exposed to sodium FA and improve some effects of intoxication. However, while this strategy resolved some signs of intoxication, ultimately it was unable to significantly reduce lethality. Using a rodent model, we assessed the effects of methylene blue (MB) and monosodium glutamate (MSG) on the neurologic, cardiac, and pulmonary systems. Results show MB and MSG can reduce neurologic signs observed in rats exposed to sodium fluoroacetate and improve some effects of intoxication. However, while this strategy resolved some signs of intoxication, ultimately it was unable to significantly reduce lethality.
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DOI：
10.1016/b978-0-12-800159-2.00016-6
发表时间：
2015-01-01
期刊：
HANDBOOK OF TOXICOLOGY OF CHEMICAL WARFARE AGENTS, 2ND EDITION
影响因子：
--
作者：
Goncharov, Nikolay;Savelieva, Elena;Kuznetsov, Anatoliy
通讯作者：
Kuznetsov, Anatoliy
影响因子：
5.5
作者：
BUFFA, P;PETERS, RA
通讯作者：
PETERS, RA
影响因子：
1.9
作者：
Eason, Charles T.;Shapiro, Lee;Statham, Helen
通讯作者：
Statham, Helen
影响因子：
3.8
作者：
Haouzi, Philippe;McCann, Marissa;Bouillaud, Frederic
通讯作者：
Bouillaud, Frederic
DOI：
10.1016/b978-0-12-374484-5.00013-4
发表时间：
2009-01-01
期刊：
HANDBOOK OF TOXICOLOGY OF CHEMICAL WARFARE AGENTS
影响因子：
--
作者：
Goncharov, Nikolay;Glashkina, Lidia;Radilov, Andrey
通讯作者：
Radilov, Andrey