Oxidative Stress and Pathogenesis in Malaria.
Oxidative Stress and Pathogenesis in Malaria.
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DOI：
10.3389/fcimb.2021.768182
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发表时间：
2021
影响因子：
5.7
通讯作者：
Rodriguez A
中科院分区：
文献类型：
--
作者：
Vasquez M;Zuniga M;Rodriguez A
疟疾是一种高度炎症性和氧化性疾病。宿主吞噬细胞产生活性氧是宿主对疟原虫感染反应的重要组成部分。此外，宿主氧化酶，如黄嘌呤氧化酶，在疟疾患者中表达上调。虽然增加活性氧的产生有助于清除寄生虫，但过量的这些自由基可以介导炎症并对宿主细胞和组织造成广泛的损害，可能导致严重的病理。疟原虫有多种抗氧化酶，使其能够在这种氧化冲击中存活下来。然而，受感染红细胞内血红蛋白的寄生降解产生游离血红素，在复制周期结束时释放，进一步加重宿主的氧化负担，并可能导致危及生命的疟疾并发症的严重程度。此外，对疟疾的高度炎症反应有助于加剧氧化反应。在这篇综述中，我们讨论宿主和寄生虫来源的氧化应激可能促进恶性疟原虫感染的严重疾病。恢复和维持疟疾患者体内氧化平衡的治疗方法可能有助于预防疟疾的致命并发症。
Malaria is a highly inflammatory and oxidative disease. The production of reactive oxygen species by host phagocytes is an essential component of the host response to Plasmodium infection. Moreover, host oxidative enzymes, such as xanthine oxidase, are upregulated in malaria patients. Although increased production of reactive oxygen species contributes to the clearance of the parasite, excessive amounts of these free radicals can mediate inflammation and cause extensive damage to host cells and tissues, probably contributing to severe pathologies. Plasmodium has a variety of antioxidant enzymes that allow it to survive amidst this oxidative onslaught. However, parasitic degradation of hemoglobin within the infected red blood cell generates free heme, which is released at the end of the replication cycle, further aggravating the oxidative burden on the host and possibly contributing to the severity of life-threatening malarial complications. Additionally, the highly inflammatory response to malaria contributes to exacerbate the oxidative response. In this review, we discuss host and parasite-derived sources of oxidative stress that may promote severe disease in P. falciparum infection. Therapeutics that restore and maintain oxidative balance in malaria patients may be useful in preventing lethal complications of this disease.
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影响因子：
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作者：
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通讯作者：
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DOI：
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期刊：
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