Temperature/Reduction Dual Response Nanogel Is Formed by In Situ Stereocomplexation of Poly (Lactic Acid).
Temperature/Reduction Dual Response Nanogel Is Formed by In Situ Stereocomplexation of Poly (Lactic Acid).
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聚乳酸原位立体络合形成温度/还原双响应纳米凝胶
DOI：
10.3390/polym13203492
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发表时间：
2021-10-12
期刊：
影响因子：
5
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Gao W;Wang Z;Song F;Fu Y;Wu Q;Liu S
采用物理交联的聚乳酸立体配位法合成了一种新型的双刺激响应纳米凝胶：将等量的聚乳酸（PLA）对映体接枝共聚物胶束溶液混合原位形成温度和还原双刺激响应凝胶；双刺激反应的特性使其在药物释放领域更具针对性。采用质子核磁共振（1H NMR）和傅里叶变换红外光谱（FT-IR）研究了凝胶的结构组成。利用透射电子显微镜（TEM）和动态光散射（DLS）仪器分析了纳米凝胶的形貌和粒径差异（表明纳米凝胶具有温度敏感性和还原性的双重刺激响应）。利用广角x射线衍射仪（WAXD）证明了聚乳酸在凝胶中的立体配位，并通过流变学试验研究了凝胶的力学性能和凝胶过程。胶束自复合再立体络合形成的物理交联凝胶网络具有更稳定的结构。结果表明，通过调节聚乳酸的聚合度，可以改变纳米凝胶的胶束性质、膨胀性质和流变性能。为制备温度/还原反应稳定的物理交联凝胶提供了一种安全实用的新方法。
A novel type of dual responsive nanogels was synthesized by physical crosslinking of polylactic acid stereocomplexation: temperature and reduction dual stimulation responsive gels were formed in situ by mixing equal amounts of PLA (Poly (Lactic Acid)) enantiomeric graft copolymer micellar solution; the properties of double stimulation response make it more targeted in the field of drug release. The structural composition of the gels was studied by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy (FT-IR). Using transmission electron microscope (TEM) and dynamic light scattering (DLS) instruments, the differences in morphology and particle size were analyzed (indicating that nanogels have dual stimulus responses of temperature sensitivity and reduction). The Wide-Angle X-ray diffractionr (WAXD) was used to prove the stereocomplexation of PLA in the gels, the mechanical properties and gelation process of the gels were studied by rheology test. The physically cross-linked gel network generated by the self-recombination of micelles and then stereo-complexation has a more stable structure. The results show that the micelle properties, swelling properties and rheological properties of nanogels can be changed by adjusting the degree of polymerization of polylactic acid. In addition, it provides a safe and practical new method for preparing stable temperature/reduction response physical cross-linked gel.
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影响因子：
29.4
作者：
Slaughter, Brandon V.;Khurshid, Shahana S.;Fisher, Omar Z.;Khademhosseini, Ali;Peppas, Nicholas A.
通讯作者：
Peppas, Nicholas A.
影响因子：
6
作者：
Buwalda, Sytze J.;Dijkstra, Pieter J.;Feijen, Jan
通讯作者：
Feijen, Jan
DOI：
10.1016/j.ijbiomac.2016.02.042
发表时间：
2016-06-01
影响因子：
8.2
作者：
Dutta, Sujan;Samanta, Pousali;Dhara, Dibakar
通讯作者：
Dhara, Dibakar
影响因子：
--
作者：
Che, Yunjiao;Zschoche, Stefan;Voit, Brigitte
通讯作者：
Voit, Brigitte
影响因子：
4.6
作者：
Pei, Yi;Molley, Thomas G.;Kilian, Kristopher A.
通讯作者：
Kilian, Kristopher A.