Hydrogels in regenerative medicine.
Hydrogels in regenerative medicine.
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DOI：
10.1002/adma.200802106
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发表时间：
2009-09-04
影响因子：
29.4
通讯作者：
Peppas, Nicholas A.
中科院分区：
文献类型：
--
作者：
Slaughter, Brandon V.;Khurshid, Shahana S.;Fisher, Omar Z.;Khademhosseini, Ali;Peppas, Nicholas A.
水凝胶由于其独特的生物相容性、灵活的合成方法、成分范围和理想的物理特性，已成为再生医学许多应用的首选材料。它们可以充当支架，为组织构建体提供结构完整性，控制药物和蛋白质向组织和培养物的递送，并充当组织和材料表面之间的粘合剂或屏障。在这项工作中，讨论了对组织工程应用重要的水凝胶的特性以及固有的材料设计限制和挑战。最近的研究涉及使用典型和新颖的合成方法从各种合成和天然单体聚合的几种不同的水凝胶。最后，特别关注目前在该领域取得重要进展的微加工技术。
Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics, have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures, and serve as adhesives or barriers between tissue and material surfaces. In this work, the properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed. Recent research involving several different hydrogels polymerized from a variety of synthetic and natural monomers using typical and novel synthetic methods are highlighted. Finally, special attention is given to the microfabrication techniques that are currently resulting in important advances in the field.
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影响因子：
10.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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