Platelets and viruses.

Platelets and viruses.
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DOI:
10.1080/09537104.2021.1887842
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发表时间:
2021-04-03
期刊:
影响因子:
3.3
通讯作者:
Mackman N
Mackman N
中科院分区:
医学3区
文献类型:
--
作者:
Antoniak S;Mackman N

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血小板在损伤后维持血管完整性方面发挥着重要作用。此外,血小板有助于对病原体的免疫反应。例如,它们表达介导病毒结合的受体,以及响应病原体相关分子模式激活细胞的toll样受体。在病毒感染期间,血小板可能是有益的,也可能是有害的。它们通过吞噬游离病毒并将病毒呈递给中性粒细胞来减少血源性病毒。然而,在病毒感染期间,血小板也会加剧炎症和组织损伤。在这里,我们将讨论血小板在病毒感染中的作用。
Platelets play an essential role in maintaining vascular integrity after injury. In addition, platelets contribute to the immune response to pathogens. For instance, they express receptors that mediate binding of viruses, and toll-like receptors that activate the cell in response to pathogen-associated molecular patterns. Platelets can be beneficial and/or detrimental during viral infections. They reduce blood-borne viruses by engulfing the free virus and presenting the virus to neutrophils. However, platelets can also enhance inflammation and tissue injury during viral infections. Here, we will discuss the roles of platelets in viral infection.
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