Greater BOLD Variability is Associated With Poorer Cognitive Function in an Adult Lifespan Sample.
Greater BOLD Variability is Associated With Poorer Cognitive Function in an Adult Lifespan Sample.
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DOI：
10.1093/cercor/bhaa243
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发表时间：
2021-01-01
期刊：
影响因子：
--
通讯作者：
Kennedy KM
中科院分区：
文献类型：
--
作者：
Boylan MA;Foster CM;Pongpipat EE;Webb CE;Rodrigue KM;Kennedy KM
Moment-to-moment fluctuations in brain signal assessed by functional magnetic resonance imaging blood oxygenation level dependent (BOLD) variability is increasingly thought to represent important “signal” rather than measurement-related “noise.” Efforts to characterize BOLD variability in healthy aging have yielded mixed outcomes, demonstrating both age-related increases and decreases in BOLD variability and both detrimental and beneficial associations. Utilizing BOLD mean-squared-successive-differences (MSSD) during a digit n-back working memory (WM) task in a sample of healthy adults (aged 20–94 years; n = 171), we examined effects of aging on whole-brain 1) BOLD variability during task (mean condition MSSD across 0–2–3-4 back conditions), 2) BOLD variability modulation to incrementally increasing WM difficulty (linear slope from 0–2–3-4 back), and 3) the association of age-related differences in variability with in- and out-of-scanner WM performance. Widespread cortical and subcortical regions evidenced increased mean variability with increasing age, with no regions evidencing age-related decrease in variability. Additionally, posterior cingulate/precuneus exhibited increased variability to WM difficulty. Notably, both age-related increases in BOLD variability were associated with significantly poorer WM performance in all but the oldest adults. These findings lend support to the growing corpus suggesting that brain-signal variability is altered in healthy aging; specifically, in this adult lifespan sample, BOLD-variability increased with age and was detrimental to cognitive performance.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
4.3
作者：
Lindenberger U;Nagel IE;Chicherio C;Li SC;Heekeren HR;Bäckman L
通讯作者：
Bäckman L
影响因子：
2.3
作者：
Depue, Brendan E.;Burgess, Gregory C.;Willcutt, Erik G.;Bidwell, L. Cinnamon;Ruzic, Luka;Banich, Marie T.
通讯作者：
Banich, Marie T.
影响因子：
16.2
作者：
Dinstein I;Heeger DJ;Lorenzi L;Minshew NJ;Malach R;Behrmann M
通讯作者：
Behrmann M
DOI：
10.1093/geronb/57.2.p101
发表时间：
2002-03-01
影响因子：
6.2
作者：
Hultsch, DF;MacDonald, SWS;Dixon, RA
通讯作者：
Dixon, RA