Age-related decline in brain resources modulates genetic effects on cognitive functioning.
Age-related decline in brain resources modulates genetic effects on cognitive functioning.
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DOI：
10.3389/neuro.01.039.2008
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发表时间：
2008-12
影响因子：
4.3
通讯作者：
Bäckman L
中科院分区：
文献类型：
--
作者：
Lindenberger U;Nagel IE;Chicherio C;Li SC;Heekeren HR;Bäckman L
认知表现的个体差异从成年早期到成年晚期增加，可能反映了多种因素的影响。我们假设，正常衰老过程中神经化学和解剖学脑资源的丧失调节了常见遗传变异对认知功能的影响。我们的假设是基于这样的假设，即大脑资源与认知的关系是非线性的，因此随着年龄的增长，随着资源从高水平向中等水平的衰退，遗传差异对认知的影响越来越大。内格尔等人的一项研究对这一假设提供了直接的实证支持，他报告说，儿茶酚-O-甲基转移酶（COMT）基因对认知能力的影响在老年时被放大，并与脑源性神经营养因子（BDNF）基因相互作用。我们的结论是，共同的遗传多态性有助于增加异质性的认知功能在老年。扩展到其他多态性的假设进行了讨论。(150（150字）
Individual differences in cognitive performance increase from early to late adulthood, likely reflecting influences of a multitude of factors. We hypothesize that losses in neurochemical and anatomical brain resources in normal aging modulate the effects of common genetic variations on cognitive functioning. Our hypothesis is based on the assumption that the function relating brain resources to cognition is nonlinear, so that genetic differences exert increasingly large effects on cognition as resources recede from high to medium levels in the course of aging. Direct empirical support for this hypothesis comes from a study by Nagel et al., who reported that the effects of the Catechol-O-Methyltransferase (COMT) gene on cognitive performance are magnified in old age and interacted with the Brain-Derived Neurotrophic Factor (BDNF) gene. We conclude that common genetic polymorphisms contribute to the increasing heterogeneity of cognitive functioning in old age. Extensions of the hypothesis to other polymorphisms are discussed. (150 of 150 words)
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DOI：
10.1093/geronb/58.4.p228
发表时间：
2003-07-01
影响因子：
6.2
作者：
Bäckman, L;Jones, S;Fratiglioni, L
通讯作者：
Fratiglioni, L
DOI：
10.1111/j.1749-6632.1993.tb23033.x
发表时间：
1993-01-01
期刊：
ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION
影响因子：
--
作者：
ANTONINI, A;LEENDERS, KL
通讯作者：
LEENDERS, KL
影响因子：
9.9
作者：
CORDER, EH;SAUNDERS, AM;HAINES, JL
通讯作者：
HAINES, JL
影响因子：
2.6
作者：
Cabeza, R;Dolcos, F;Nyberg, L
通讯作者：
Nyberg, L
影响因子：
3.2
作者：
de Frias, CM;Annerbrink, K;Nilsson, LR
通讯作者：
Nilsson, LR