Molecular imaging of vessels in mouse models of disease.
Molecular imaging of vessels in mouse models of disease.
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小鼠疾病模型中血管的分子成像。
DOI：
10.1016/j.ejrad.2009.01.053
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发表时间：
2009-05
影响因子：
3.3
通讯作者：
Mulligan-Kehoe, Mary J.
中科院分区：
文献类型：
--
作者：
Zagorchev, Lyubomir;Mulligan-Kehoe, Mary J.
疾病小鼠血管生成模型的血管成像需要多模态成像硬件，能够在不同的物理尺度上靶向结构和功能。三维（3D）结构和功能血管信息允许生物过程之间的准确区分。例如，血管生成与动脉生成的血管发育图像分析可以更准确地检测受试者之间的生物学差异，并更可靠地诊断疾病。近年来，该领域出现了许多微成像模式，作为实现这一目的的首选手段。它们提供适合于动物模型结果分析、量化、验证和可视化的3D体积数据。本文综述了微ct、超声和微pet在小鼠肿瘤血管生成模型中血管生成和分子血管靶点的多模态成像能力。描述了成像模式的基本原理，并给出了实验结果。
Vascular imaging of angiogenesis in mouse models of disease requires multi modal imaging hardware capable of targeting both structure and function at different physical scales. The three dimensional (3D) structure and function vascular information allows for accurate differentiation between biological processes. For example, image analysis of vessel development in angiogenesis vs. arteriogenesis enables more accurate detection of biological variation between subjects and more robust and reliable diagnosis of disease. In the recent years a number of micro imaging modalities have emerged in the field as preferred means for this purpose. They provide 3D volumetric data suitable for analysis, quantification, validation, and visualization of results in animal models. This review highlights the capabilities of microCT, ultrasound and microPET for multimodal imaging of angiogenesis and molecular vascular targets in a mouse model of tumor angiogenesis. The basic principles of the imaging modalities are described and experimental results are presented.
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影响因子：
1.8
作者：
Cherry, SR;Shao, Y;Phelps, ME
通讯作者：
Phelps, ME
DOI：
10.1007/s00259-003-1452-2
发表时间：
2004-08-01
影响因子：
9.1
作者：
Chen, XY;Park, R;Conti, PS
通讯作者：
Conti, PS
影响因子：
--
作者：
Engelke, K;Karolczak, M;Kalender, W
通讯作者：
Kalender, W
影响因子：
82.9
作者：
ALON, T;HEMO, I;KESHET, E
通讯作者：
KESHET, E
DOI：
10.1007/s004290050225
发表时间：
1999-03-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
Graichen, H;Lochmüller, EM;Eckstein, F
通讯作者：
Eckstein, F