Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen.
Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen.
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DOI：
10.1038/s41467-018-04520-1
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发表时间：
2018-06-07
影响因子：
16.6
通讯作者：
Wilkinson B
中科院分区：
文献类型：
--
作者：
Heine D;Holmes NA;Worsley SF;Santos ACA;Innocent TM;Scherlach K;Patrick EH;Yu DW;Murrell JC;Vieria PC;Boomsma JJ;Hertweck C;Hutchings MI;Wilkinson B
顶切叶蚁与真菌 Leucoagaricus gogylophorus 和假诺卡氏菌形成互利共生。两者都是垂直传播并由蚂蚁主动维持。真菌花园用新鲜切下的叶子施肥，为蚂蚁幼虫提供唯一的食物，而假诺卡氏菌培养物则在蚂蚁角质层上生长，并产生抗真菌代谢物，以帮助保护品种免受疾病侵害。如果不加以控制，特殊的寄生Escovopsis真菌可能会超出真菌花园并导致菌落崩溃。我们报告说，当 Escovopsis 感染该品种时，它会上调两种特殊代谢物的产生。这些化合物可抑制假诺卡氏菌，其中一种化合物希里宁 D 也会降低工蚁的行为防御能力，当它在蚂蚁组织中积聚时最终会致命。我们的结果与假诺卡氏菌和Escovopsis之间活跃的进化军备竞赛一致，它改变了细菌和行为防御，一旦Escovopsis感染升级，菌落崩溃是不可避免的。顶膜蚁培育的真菌花园可能会被 Escovopsis sp. 寄生，导致蚁群崩溃。在这里，海涅等人。鉴定了 Escovopsis 产生的两种次生代谢物，它们在 Acromyrmex 组织中积累，减少行为防御并抑制共生假诺卡氏菌。
Acromyrmex leafcutter ants form a mutually beneficial symbiosis with the fungus Leucoagaricus gongylophorus and with Pseudonocardia bacteria. Both are vertically transmitted and actively maintained by the ants. The fungus garden is manured with freshly cut leaves and provides the sole food for the ant larvae, while Pseudonocardia cultures are reared on the ant-cuticle and make antifungal metabolites to help protect the cultivar against disease. If left unchecked, specialized parasitic Escovopsis fungi can overrun the fungus garden and lead to colony collapse. We report that Escovopsis upregulates the production of two specialized metabolites when it infects the cultivar. These compounds inhibit Pseudonocardia and one, shearinine D, also reduces worker behavioral defenses and is ultimately lethal when it accumulates in ant tissues. Our results are consistent with an active evolutionary arms race between Pseudonocardia and Escovopsis, which modifies both bacterial and behavioral defenses such that colony collapse is unavoidable once Escovopsis infections escalate. Acromyrmex ants cultivate fungus gardens that can be parasitized by Escovopsis sp., leading to colony collapse. Here, Heine et al. identify two secondary metabolites produced by Escovopsis that accumulate in Acromyrmex tissue, reduce behavioural defenses and suppress symbiotic Pseudonocardia bacteria.
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影响因子：
4.9
作者：
Andersen SB;Hansen LH;Sapountzis P;Sørensen SJ;Boomsma JJ
通讯作者：
Boomsma JJ
影响因子：
3.4
作者：
de Bekker C;Quevillon LE;Smith PB;Fleming KR;Ghosh D;Patterson AD;Hughes DP
通讯作者：
Hughes DP
影响因子：
3.3
作者：
ARGOUDELIS, AD;REUSSER, F
通讯作者：
REUSSER, F
影响因子：
4.3
作者：
Dhodary, Basanta;Schilg, Michele;Spiteller, Dieter
通讯作者：
Spiteller, Dieter
DOI：
10.1098/rspb.2015.0212
发表时间：
2015-05-22
影响因子：
4.7
作者：
Fernandez-Marin, Hermogenes;Nash, David R.;Boomsma, Jacobus J.
通讯作者：
Boomsma, Jacobus J.