Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19.
Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19.
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DOI：
10.1016/j.mehy.2020.110340
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发表时间：
2020-12
影响因子：
4.7
通讯作者：
Egea FM
中科院分区：
文献类型：
--
作者：
Regidor PA;Santos FG;Rizo JM;Egea FM
SPMs是一种很有前途的物质，建议开展临床试验，以测试其激活肺部炎症消退的能力。SPMs可以减轻COVID - 19患者的组织损伤，影响细胞因子风暴。重点可能是辅助管理或改善和解决慢性肺和心脏炎症在急性期后的疾病。COVID-19是由冠状病毒SARS-CoV-2引起的一种新型疾病。它于2019年首次被描述，于2020年1月发展成为流行病，并已在全球传播到目前的COVID-19大流行。特异性促溶解介质（SPMs）可能在这种肺部疾病的治疗中发挥新的作用，因为SPM积极刺激感染性炎症的消退，并在动物疾病模型中具有器官保护作用。许多组织已成为SPMs或其活性前体18-HEPE， 17-HDHA和14-HDHA治疗炎症的合适靶点，以引发炎症的动态解决。在这里，我们讨论这些物质在SARS Covid - 19管理中的可能作用模式。
SPMs are promising substances and suggest a clinical trial be initiated to test their ability to activate resolution of lung inflammation. SPMs could reduce tissue damage in COVID 19 patients to influence the cytokine storm. The focus could be in the adjuvant management or for the improvement and resolution of chronic lung and heart inflammation in the post-acute phase of this disease. COVID-19 is a new disease caused by coronavirus SARS-CoV-2. It was first described in 2019, developed into an epidemic in January 2020 and has spread the global to the present COVID-19 pandemic. Specialized pro‑resolving mediators (SPMs) may play a new role in the management of this lung disease because SPM actively stimulate the resolution of infectious inflammation and are organ protective in animal disease models. Many tissues have been suitable targets for treating inflammation with SPMs or their active precursors 18-HEPE, 17-HDHA and the 14-HDHA, in order to elicit dynamic resolution of inflammation. Here we discuss the possible mode of action of these substances in the management of SARS Covid 19.
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影响因子：
4
作者：
Serhan, Charles N.;Chiang, Nan
通讯作者：
Chiang, Nan
DOI：
10.1016/j.bbalip.2014.08.006
发表时间：
2015-04
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
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通讯作者：
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影响因子：
7.3
作者：
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通讯作者：
Flower, RJ
DOI：
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发表时间：
2000-10-16
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
Gronert K
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin