Parenteral Antioxidant Supplementation at Birth Improves the Response to Intranasal Vaccination in Newborn Dairy Calves.
Parenteral Antioxidant Supplementation at Birth Improves the Response to Intranasal Vaccination in Newborn Dairy Calves.
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DOI：
10.3390/antiox10121979
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发表时间：
2021-12-12
期刊：
影响因子：
--
通讯作者：
Abuelo A
中科院分区：
文献类型：
--
作者：
Nayak A;Abuelo A
新生牛犊在其生命的第一个月经历氧化应激，这是已知的降低与疫苗反应性相关的淋巴细胞功能。因此，本研究旨在确定出生时给予肠外抗氧化剂补充剂在多大程度上改善了新生奶牛出生后第一个月对鼻内病毒疫苗的反应。为此，21头小牛在出生时被随机分配到两种市售抗氧化微量营养素补充剂中的一种，或接受0.9%无菌生理盐水的安慰剂组（n = 7/组）。在给予呼吸道病毒（牛疱疹病毒1型、牛合胞呼吸道病毒和副流感病毒3型）的治疗和鼻内疫苗之前收集血清和鼻分泌物样本，并在年龄的前四周每周收集一次。测定血清中系统性氧化还原平衡。对牛疱疹病毒1和牛合胞呼吸道病毒特异性免疫球蛋白A在鼻分泌物中定量作为鼻内疫苗反应性的代理。我们的研究结果表明，出生时肠外注射抗氧化剂可以改善小牛的氧化还原平衡。此外，添加抗氧化剂的犊牛鼻分泌物中免疫球蛋白A的浓度高于对照组。因此，我们得出结论，在出生时补充抗氧化剂可能是改善鼻内疫苗反应的实用策略。未来更大规模的研究应评估鼻内疫苗接种增加的粘膜反应能在多大程度上降低小牛的发病率和死亡率。
Newborn calves experience oxidative stress throughout the first month of their life, which is known to decrease lymphocyte functions relevant to vaccine responsiveness. Thus, this study aimed to determine the extent to which parenteral antioxidant supplementation given at birth improves the response to an intranasal viral vaccine in the first month of life of newborn dairy calves. For this, 21 calves were randomly assigned at birth to one of two commercially available antioxidant micronutrient supplements or a placebo group receiving 0.9% sterile saline (n = 7/group). Serum and nasal secretion samples were collected before administration of treatments and an intranasal vaccine against respiratory viruses (bovine herpesvirus type 1, bovine syncytial respiratory virus, and parainfluenza 3), and once weekly for the first four weeks of age. Systemic redox balance was determined in serum. Immunoglobulin A specific for bovine herpesvirus 1 and bovine syncytial respiratory virus was quantified in nasal secretions as a proxy to intranasal vaccine responsiveness. Our results showed that parenteral administration of antioxidants at birth improved calves’ redox balance. Additionally, calves receiving antioxidant supplementation had higher concentrations of immunoglobulin A in their nasal secretions than calves in the control group. Thus, we conclude that supplementation of calves with antioxidants at birth could be a practical strategy to improve intranasal vaccine response. Future larger studies should evaluate the extent to which this increased mucosal response to intranasal vaccination could result in decreased calf morbidity and mortality.
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影响因子：
3.5
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