Stem cell populations in the heart and the role of Isl1 positive cells.
Stem cell populations in the heart and the role of Isl1 positive cells.
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DOI：
10.4081/ejh.2013.e14
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发表时间：
2013-05-09
期刊：
影响因子：
--
通讯作者：
Zummo G
中科院分区：
文献类型：
--
作者：
Di Felice V;Zummo G
心脏前体细胞是从胚胎和成人心脏中分离出来的多能干细胞，至少能够分化为平滑肌细胞、内皮细胞和心肌细胞。这些细胞的胚胎起源尚未得到证实，但已有研究表明，这些细胞可能来自第一和第二心脏区域以及神经脊。在过去的十年中，已经鉴定和分离了两种不同的心脏祖细胞或干细胞，即Islet1阳性(Isl1+)和c-Kit阳性(c-Kit+)/干细胞抗原-1(SCA-1+)细胞。直到2012年，这两个群体一直被认为是两个不同的实体，具有不同的作用和不同的起源，但现在新的证据表明，这两个群体之间存在联系，这两个群体可能代表着一个独特的心脏干细胞池的两个亚群，来自共同的未成熟原始细胞。在这一概念上找到共同的共识，对于进一步推动干细胞在心脏组织工程中的应用是非常重要的。
Cardiac progenitor cells are multipotent stem cells isolated from both embryonic and adult hearts in several species and are able to differentiate at least into smooth muscle cells, endothelial cells and cardiomyocytes. The embryonic origin of these cells has not yet been demonstrated, but it has been suggested that these cells may derive from the first and secondary heart fields and from the neural crest. In the last decade, two different populations of cardiac progenitor or stem cells have been identified and isolated, i.e., the Islet1 positive (Isl1+) and c-Kit positive (c-Kit+)/Stem Cell Antigen-1 positive (Sca-1+) cells. Until 2012, these two populations have been considered two separate entities with different roles and a different origin, but new evidence now suggests a connection between the two populations and that the two populations may represent two subpopulations of a unique pool of cardiac stem cells, derived from a common immature primitive cell. To find a common consensus on this concept is very important in furthering the application of stem cells to cardiac tissue engineering.
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DOI：
10.1126/science.1177350
发表时间：
2009-10-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Domian IJ;Chiravuri M;van der Meer P;Feinberg AW;Shi X;Shao Y;Wu SM;Parker KK;Chien KR
通讯作者：
Chien KR
影响因子：
2.4
作者：
Pandur P;Sirbu IO;Kühl SJ;Philipp M;Kühl M
通讯作者：
Kühl M
影响因子：
20.1
作者：
Ferreira-Martins J;Ogórek B;Cappetta D;Matsuda A;Signore S;D'Amario D;Kostyla J;Steadman E;Ide-Iwata N;Sanada F;Iaffaldano G;Ottolenghi S;Hosoda T;Leri A;Kajstura J;Anversa P;Rota M
通讯作者：
Rota M
影响因子：
5.6
作者：
Di Felice, Valentina;Ardizzone, Nella Maria;Zummo, Giovanni
通讯作者：
Zummo, Giovanni
DOI：
10.1002/ar.20858
发表时间：
2009-03-01
影响因子：
2
作者：
Di Felice, Valentina;De Luca, Angela;Zummo, Giovanni
通讯作者：
Zummo, Giovanni