Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population.
Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population.
复制标题
TCF7L2 多态性与中国人群 2 型糖尿病风险关联的 Meta 分析。
DOI：
10.1186/1471-2350-14-8
复制
发表时间：
2013-01-12
影响因子：
--
通讯作者：
Hu D
中科院分区：
文献类型：
--
作者：
Wang J;Hu F;Feng T;Zhao J;Yin L;Li L;Wang Y;Wang Q;Hu D
转录因子7样2（TCF 7 L2）多态性与2型糖尿病（T2 DM）之间的关联已在多个种族群体中进行了广泛评估。TCF 7 L2已成为欧洲人中最强的T2 DM易感基因，但在中国人群中的发现并不一致。本荟萃分析的目的是评估中国人群中TCF 7 L2单核苷酸多态性（SNP）与2型糖尿病风险之间的关联。我们在PubMed、EMBASE、科克伦和中文数据库（CNKI、CQVIP和万方数据库）中检索了2007年1月至2012年2月发表的文献。我们回顾了所有关于中国人群TCF 7 L2多态性与T2 DM易感性的中英文相关文章。两名审查员使用标准化方案独立提取数据，任何差异由第三名审查员裁定。进行了固定效应和随机效应荟萃分析，以汇总比值比（OR）。检查了发表偏倚和异质性。共有21篇文章被确认符合并纳入本荟萃分析：7（3942例病例和3502例对照）关于rs 11196218（IVS−/+4G>A），8 rs 290487（IVS 3-/+C>T）14例（IVS 3-/+C>T），7902例（IVS 3-/+C>T），7436例（对照）。总体而言，结果显示rs7903146与T2 DM风险之间存在显着相关性。T和C等位基因比较的合并OR为1.54（95% CI [置信区间]：1.37-1.74，p = 1.47 × 10-12，I2 = 25.20%），TC杂合子和CC纯合子的合并OR为1.56（95% CI：1.38-1.76，p = 8.25 × 10-9，I2 = 21.00%）。rs 11196218（IVS 4G>A）和rs 290487（IVS 3C>T）SNPs与T2 DM风险无关。TCF 7 L2基因的rs7903146 SNP与中国总体人群以及中国北方和南方人群中T2 DM易感性增加相关。
Associations between transcription factor 7-like 2 (TCF7L2) polymorphisms and type 2 diabetes mellitus (T2DM) have been evaluated extensively in multiple ethnic groups. TCF7L2 has emerged as the strongest T2DM susceptibility gene in Europeans, but the findings have been inconsistent in the Chinese population. The purpose of this meta-analysis was to evaluate the associations between TCF7L2 single nucleotide polymorphisms (SNPs) and T2DM risk in the Chinese population. We performed searches in the PubMed, EMBASE, Cochrane, and Chinese databases (CNKI, CQVIP and Wanfang databases) for literature published from January 2007 to February 2012. We reviewed all relevant articles on TCF7L2 polymorphisms and susceptibility to T2DM in the Chinese population written in English and Chinese. Two reviewers extracted data independently using a standardized protocol, and any discrepancies were adjudicated by a third reviewer. Fixed-effects and random-effects meta-analyses were performed to pool the odds ratios (ORs). Publication bias and heterogeneity were examined. A total of 21 articles were confirmed to be eligible for and included in this meta-analysis: 7 (with 3942 cases and 3502 controls) concerning rs11196218 (IVS−/+4G>A), 8 (with 3377 cases and 2975 controls) concerning rs290487 (IVS3−/+C>T), and 14 (with 7902 cases and 7436 controls) concerning rs7903146 (IVS3−/+C>T). Overall, the results showed a significant association between rs7903146 and T2DM risk. The pooled ORs were 1.54 for the comparison of T and C alleles (95% CI [confidence interval]: 1.37–1.74, p = 1.47 × 10-12, I2 = 25.20%) and 1.56 for TC heterozygotes and CC homozygotes (95% CI : 1.38–1.76, p = 8.25 × 10-9, I2 = 21.00%). The rs11196218(IVS4G>A) and rs290487 (IVS3C>T) SNPs were not associated with T2DM risk. The rs7903146 SNP of the TCF7L2 gene is associated with increased susceptibility to T2DM in the Chinese population as a whole as well as northern Chinese and southern Chinese as subgroups.
登录
查看更多内容
全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
影响因子：
7.7
作者：
Chang, Yi-Cheng;Chang, Tien-Jyun;Chuang, Lee-Ming
通讯作者：
Chuang, Lee-Ming
影响因子：
3.6
作者：
MIDGETTE, AS;WONG, JB;PAUKER, SG
通讯作者：
PAUKER, SG
DOI：
10.1016/j.anngen.2004.05.004
发表时间：
2004-10-01
期刊：
ANNALES DE GENETIQUE
影响因子：
--
作者：
Flores-Martínez, SE;Islas-Andrade, S;Sánchez-Corona, J
通讯作者：
Sánchez-Corona, J
影响因子：
16.2
作者：
King, H;Aubert, RE;Herman, WH
通讯作者：
Herman, WH