Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo.
Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivo.
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DOI：
10.1002/mrm.22450
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发表时间：
2010-11
影响因子：
3.3
通讯作者：
Boada, Fernando E.
中科院分区：
文献类型：
--
作者：
Qian, Yongxian;Williams, Ashley A.;Chu, Constance R.;Boada, Fernando E.
关键词：
胶原纤维的紊乱是膝关节骨关节炎早期软骨退化的标志。被截留在组织良好的胶原纤维内的水分子将对胶原改变敏感。多组分T2* 映射与超短回波时间（UTE）收购在这里提出了探测短T2弛豫在这些被困的水分子。在3 T MRI扫描仪上使用自制的UTE序列扫描6个人胫骨平台外植体，通过Monte Carlo模拟优化TE。T2* 衰变的时间常数和组分强度使用非负最小二乘算法在单个像素处计算。发现四种T2* 衰减类型：99%的软骨像素具有单指数、双指数或非指数衰减，1%显示三指数衰减。短T2* 主要在1- 6 ms，长T2* 在~ 22 ms。衰变类型图显示了这些T2* 衰变的空间分布。这些结果显示了在人膝关节软骨外植体上进行多组分T2* 映射的技术可行性。
Disorganization of collagen fibers is a sign of early-stage cartilage degeneration in osteoarthritis knees. Water molecules trapped within well-organized collagen fibrils would be sensitive to collagen alterations. Multi-component T2* mapping with ultrashort echo time (UTE) acquisitions is here proposed to probe short T2 relaxations in those trapped water molecules. Six human tibial plateau explants were scanned on a 3T MRI scanner using a home-developed UTE sequence with TEs optimized via Monte Carlo simulations. Time constants and component intensities of T2* decays were calculated at individual pixels using the nonnegative least squares algorithm. Four T2*-decay types were found: 99% of cartilage pixels having mono-, bi-, or non-exponential decay, and 1% showing tri-exponential decay. Short T2* was mainly in 1-6ms while long T2* was ~22ms. A map of decay types presented spatial distribution of these T2* decays. These results showed the technical feasibility of multi-component T2* mapping on human knee cartilage explants.
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影响因子：
7
作者：
Williams, A.;Qian, Y.;Bear, D.;Chu, C. R.
通讯作者：
Chu, C. R.
影响因子：
3.3
作者：
Shapiro, EM;Borthakur, A;Reddy, R
通讯作者：
Reddy, R
影响因子：
7
作者：
Mosher, TJ;Chen, Q;Smith, MB
通讯作者：
Smith, MB
影响因子：
19.7
作者：
FULLERTON, GD;CAMERON, IL;ORD, VA
通讯作者：
ORD, VA
影响因子：
3.3
作者：
Miller, KL;Hargreaves, BA;Pauly, JM
通讯作者：
Pauly, JM