Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits.
Template MRI scans reliably approximate individual and group-level tES and TMS electric fields induced in motor and prefrontal circuits.
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模板MRI扫描可靠地近似于电动机和前额叶电路中引起的单个和组级TE和TMS电场。
DOI：
10.3389/fncir.2023.1214959
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发表时间：
2023
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
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作者：
电场（E-field）建模是阐明经颅磁刺激（TMS）和经颅电刺激（tES）的皮层靶接触的一种有价值的方法，但它通常依赖于单个MRI扫描。在这项研究中，我们系统地测试了模板ni -152和Ernie扫描中的电磁场模型是否能够可靠地近似5种诊断（健康、酒精使用障碍、烟草使用障碍、焦虑、抑郁）中N = 195个人的群体水平电磁场。我们使用CHARM-SimNIBS 4.0.0流水线计算了788个电子场模型，每个参与者有4个电子场模型（TMS和tES的运动和前额叶目标）。我们还计算了排列分析来确定电场的稳定点，以评估在MNI-152模板中所代表的152个大脑是否足够。个体与MNI-152模板和Ernie扫描在任何刺激方式或位置上的组水平电场没有显著差异（p > 0.05）。然而，经颅磁刺激诱发的电场强度因诊断而有显著差异；广泛性焦虑症患者的前额叶和运动电场强度显著高于健康对照组和酒精使用障碍和抑郁症患者（p < 0.001）。组水平电场的稳定点范围从42（运动te）到52（前额叶TMS）。MNI-152和Ernie模型可靠地估计组平均TMS和tes诱导的电磁场。MNI-152模板包括足够的扫描，以控制个体间的解剖差异（即稳定点以上）。总的来说，使用MNI-152和Ernie大脑来近似群体水平的电场是一种有效和可靠的方法。
Electric field (E-field) modeling is a valuable method of elucidating the cortical target engagement from transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), but it is typically dependent on individual MRI scans. In this study, we systematically tested whether E-field models in template MNI-152 and Ernie scans can reliably approximate group-level E-fields induced in N = 195 individuals across 5 diagnoses (healthy, alcohol use disorder, tobacco use disorder, anxiety, depression). We computed 788 E-field models using the CHARM–SimNIBS 4.0.0 pipeline with 4 E-field models per participant (motor and prefrontal targets for TMS and tES). We additionally calculated permutation analyses to determine the point of stability of E-fields to assess whether the 152 brains represented in the MNI-152 template is sufficient. Group-level E-fields did not significantly differ between the individual vs. MNI-152 template and Ernie scans for any stimulation modality or location (p > 0.05). However, TMS-induced E-field magnitudes significantly varied by diagnosis; individuals with generalized anxiety had significantly higher prefrontal and motor E-field magnitudes than healthy controls and those with alcohol use disorder and depression (p < 0.001). The point of stability for group-level E-field magnitudes ranged from 42 (motor tES) to 52 participants (prefrontal TMS). MNI-152 and Ernie models reliably estimate group-average TMS and tES-induced E-fields transdiagnostically. The MNI-152 template includes sufficient scans to control for interindividual anatomical differences (i.e., above the point of stability). Taken together, using the MNI-152 and Ernie brains to approximate group-level E-fields is a valid and reliable approach.
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