Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation.
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation.
复制标题
重复神经调节的老年人的长期工作记忆和长期记忆的长期改善。
DOI：
10.1038/s41593-022-01132-3
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发表时间：
2022-09
影响因子：
25
通讯作者：
Reinhart, Robert M. G.
中科院分区：
文献类型：
--
作者：
Grover, Shrey;Wen, Wen;Viswanathan, Vighnesh;Gill, Christopher T.;Reinhart, Robert M. G.
开发保护或增强老年人记忆的技术是转化医学的一个长期目标。在这里，我们描述了重复（4天）经颅交流电刺激（tACS）方案选择性，可持续地增强65 - 88岁人群的听觉-言语工作记忆和长期记忆。在干预后第3天、第4天和第1个月，调节顶叶皮层同步低频而非高频活动优先改善工作记忆；而在干预后第2-4天和第1个月，调节前额叶皮层同步高频而非低频活动优先改善长期记忆。4天内记忆改善的速度预测了1个月后记忆改善的大小。认知功能基线较低的个体经历了更大、更持久的记忆改善。我们的研究结果表明，老化大脑的可塑性可以通过基于记忆特异性皮层回路的空间光谱参数的重复和高度聚焦的神经调节来选择性和可持续地利用。
The development of technologies to protect or enhance memory in older people is an enduring goal of translational medicine. Here we describe repetitive (4-day) transcranial alternating current stimulation (tACS) protocols for the selective, sustainable enhancement of auditory-verbal working memory and long-term memory in 65–88-year-old people. Modulation of synchronous low-frequency, but not high-frequency, activity in parietal cortex preferentially improved working memory on day 3 and day 4 and 1 month after intervention, whereas modulation of synchronous high-frequency, but not low-frequency, activity in prefrontal cortex preferentially improved long-term memory on days 2–4 and 1 month after intervention. The rate of memory improvements over 4 days predicted the size of memory benefits 1 month later. Individuals with lower baseline cognitive function experienced larger, more enduring memory improvements. Our findings demonstrate that the plasticity of the aging brain can be selectively and sustainably exploited using repetitive and highly focalized neuromodulation grounded in spatiospectral parameters of memory-specific cortical circuitry.
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影响因子：
19.9
作者：
Herweg NA;Solomon EA;Kahana MJ
通讯作者：
Kahana MJ
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作者：
Edwards, Dylan;Cortes, Mar;Datta, Abhishek;Minhas, Preet;Wassermann, Eric M.;Bikson, Marom
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