Striatal hypoactivation during monetary loss anticipation in individuals with substance use disorders in a heterogenous urban American Indian sample.
Striatal hypoactivation during monetary loss anticipation in individuals with substance use disorders in a heterogenous urban American Indian sample.
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DOI：
10.1016/j.drugalcdep.2023.109852
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发表时间：
2023-05-01
影响因子：
4.2
通讯作者：
White, Evan J.
中科院分区：
文献类型：
--
作者：
Wilhelm, Ricardo A.;Spechler, Philip A.;Demuth, Mara J.;Gonzalez, Miigis;Kemp, Christopher;Walls, Melissa;Aupperle, Robin L.;Paulus, Martin P.;Stewart, Jennifer L.;White, Evan J.
研究表明，不成比例地暴露于风险因素使美国印第安人（AI）处于物质使用障碍（SUD）的高风险之中。虽然SUD与纹状体优先考虑药物奖励而不是其他食欲刺激有关，但在与调查厌恶性估值处理和纳入AI样本相关的文献中存在差距。为了解决这些差距，本研究比较了塔尔萨1000研究中在功能磁共振成像期间完成货币激励延迟（MID）任务的AI识别SUD（SUD+; n = 52）和无SUD（SUD-; n = 35）组之间的纹状体预期增益和损失处理。结果表明，纹状体激活的中脑核（NAcc），尾状核，壳核是最大的预期收益（ps < 0.001），但没有显示组间差异。与收益相比，SUD+表现出较低的NAcc（p = 0.01，d =0.53）和壳核（p = 0.04，d =0.40）激活，以预期比对照组大的损失。在SUD+中，预期损失期间较低的纹状体反应与损失试验期间较慢的MID反应时间（NAcc：r =-0.43;壳核：r =-0.35）相关。这是第一个成像研究，以检查与SUD在AI内相关的潜在神经机制。衰减损失处理提供了一个潜在机制的初步证据，其中对令人厌恶的后果的迟钝预测可能是SUD的一个定义特征，可以为未来的预防和干预目标提供信息。
Research suggests that disproportionate exposure to risk factors places American Indian (AI) peoples at higher risk for substance use disorders (SUD). Although SUD is linked to striatal prioritization of drug rewards over other appetitive stimuli, there are gaps in the literature related to the investigation of aversive valuation processing, and inclusion of AI samples. To address these gaps, this study compared striatal anticipatory gain and loss processing between AI-identified with SUD (SUD+; n = 52) and without SUD (SUD−; n = 35) groups from the Tulsa 1000 study who completed a monetary incentive delay (MID) task during functional magnetic resonance imaging. Results indicated that striatal activations in the nucleus accumbens (NAcc), caudate, and putamen were greatest for anticipating gains (ps < 0.001) but showed no group differences. In contrast to gains, the SUD+ exhibited lower NAcc (p = .01, d =0.53) and putamen (p = .04, d =0.40) activation to anticipating large losses than the comparison group. Within SUD+ , lower striatal responses during loss anticipations were associated with slower MID reaction times (NAcc: r = −0.43; putamen: r = −0.35) during loss trials. This is among the first imaging studies to examine underlying neural mechanisms associated with SUD within AIs. Attenuated loss processing provides initial evidence of a potential mechanism wherein blunted prediction of aversive consequences may be a defining feature of SUD that can inform future prevention and intervention targets.
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DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
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作者：
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