Experimental infection of cats and dogs with West Nile virus.
Experimental infection of cats and dogs with West Nile virus.
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DOI：
10.3201/eid1001.020616
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发表时间：
2004-01
影响因子：
11.8
通讯作者：
Chang GJ
中科院分区：
文献类型：
--
作者：
Austgen LE;Bowen RA;Bunning ML;Davis BS;Mitchell CJ;Chang GJ
家养狗和猫被蚊虫叮咬感染，被评价为西尼罗病毒（WNV）宿主。在4只狗中出现了低强度和短时间的病毒血症，但它们没有表现出疾病的迹象。4只猫出现病毒血症，峰值滴度在103.0 ~ 104.0 PFU/mL之间。其中三只猫表现出轻微的非神经系统疾病症状。在病毒血症期间，没有从狗或猫的唾液中分离到西尼罗河病毒。另外一组4只猫通过摄入受感染的老鼠而口服暴露于西尼罗河病毒。两只猫连续三天吃一只受感染的老鼠，两只猫吃一只受感染的老鼠。所有这些猫都出现了病毒血症，其程度和持续时间与被蚊子叮咬感染的猫相似，但这四只猫都没有表现出临床症状。这些结果表明狗和猫很容易被西尼罗河病毒感染。在猫中观察到的高效率的口腔传播表明，受感染的猎物可能是食肉动物感染的重要来源。这两个物种都不太可能成为流行病学上重要的扩增宿主，尽管在猫身上观察到的病毒血症峰值可能高到足以以低效率感染蚊子。
Domestic dogs and cats were infected by mosquito bite and evaluated as hosts for West Nile virus (WNV). Viremia of low magnitude and short duration developed in four dogs but they did not display signs of disease. Four cats became viremic, with peak titers ranging from 103.0 to 104.0 PFU/mL. Three of the cats showed mild, non-neurologic signs of disease. WNV was not isolated from saliva of either dogs or cats during the period of viremia. An additional group of four cats were exposed to WNV orally, through ingestion of infected mice. Two cats consumed an infected mouse on three consecutive days, and two cats ate a single infected mouse. Viremia developed in all of these cats with a magnitude and duration similar to that seen in cats infected by mosquito bite, but none of the four showed clinical signs. These results suggest that dogs and cats are readily infected by WNV. The high efficiency of oral transmission observed with cats suggests that infected prey animals may serve as an important source of infection to carnivores. Neither species is likely to function as an epidemiologically important amplifying host, although the peak viremia observed in cats may be high enough to infect mosquitoes at low efficiency.
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影响因子：
2.1
作者：
Turell, MJ;O'Guinn, ML;Jones, JW
通讯作者：
Jones, JW
影响因子：
9.4
作者：
Garmendia, AE;Van Kruiningen, HJ;West, AB
通讯作者：
West, AB
DOI：
10.1016/0035-9203(82)90132-8
发表时间：
1982-01-01
影响因子：
2.2
作者：
AKHTER, R;HAYES, CG;REISEN, WK
通讯作者：
REISEN, WK
DOI：
10.20506/rst.19.1.1201
发表时间：
2000-04-01
影响因子：
0.6
作者：
Komar, N
通讯作者：
Komar, N
影响因子：
0.8
作者：
BLACKBURN, NK;REYERS, F;SHEPHERD, AJ
通讯作者：
SHEPHERD, AJ