[F-18]-fluorodeoxyglucose PET-CT of the normal prostate gland.
[F-18]-fluorodeoxyglucose PET-CT of the normal prostate gland.
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DOI：
10.1007/s12149-008-0177-5
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发表时间：
2008-11
影响因子：
2.6
通讯作者：
Conti, Peter S.
中科院分区：
文献类型：
--
作者：
Jadvar, Hossein;Ye, Wei;Groshen, Susan;Conti, Peter S.
我们在[F-18]氟脱氧葡萄糖正电子发射断层扫描（PET）-CT上确定了正常前列腺的葡萄糖代谢和计算机断层扫描（CT）密度与年龄和前列腺大小的关系。我们在PET-CT扫描中确定了145名男性（年龄范围22 - 97岁）正常前列腺的CT密度（Hounsfield单位，HU）和葡萄糖代谢（标准化摄取值，SUV），这些扫描是针对与前列腺病理无关的适应症进行的。SUV、HU、前列腺大小和年龄之间的相关性采用Pearson相关系数、散点图和线性回归趋势线进行计算。还使用Kruskal-Wallis检验比较了不同原发性癌症类型之间的SUV和HU值。正常前列腺大小的群体平均值和范围分别为4.3 ± 0.5 cm（均值± SD）和2.9 - 5.5 cm。平均和最大CT密度的群体平均值分别为36.0 ± 5.1 HU（范围23 - 57）和91.7 ± 20.1 HU（范围62 - 211）。平均和最大SUV的群体平均值分别为1.3 ± 0.4（范围0.1 - 2.7）和1.6 ± 0.4（范围1.1 - 3.7）。随着前列腺大小的增加，平均SUV趋于降低（r =-0.16，P = 0.058）。较高的平均HU与较高的平均SUV相关（r = 0.18，P = 0.033）。年龄和前列腺大小之间的关联最强。前列腺体积随年龄增长而增大（r = 0.32，P <0.001）。前列腺平均SUV、最大SUV、平均HU和最大HU在不同类型的原发癌之间没有显著差异。虽然正常前列腺大小随年龄增长而增加，但它不会显著影响腺体的代谢和CT密度，因此这些参数的年龄校正可能是不必要的。
We determined the glucose metabolism and computed tomographic (CT) density of the normal prostate gland in relation to age and prostate size on [F-18] fluorodeoxyglucose positron emission tomography (PET)–CT. We determined the CT density (Hounsfield Units, HU) and glucose metabolism (standardized uptake value, SUV) of the normal prostate in 145 men (age range 22–97 years) on PET–CT scans which were performed for indications unrelated to prostate pathology. Correlations among SUV, HU, prostate size, and age were calculated using Pearson’s correlation coefficients, scatter plots, and linear regression trend lines. The SUV and HU values were also compared among different primary cancer types using the Kruskal–Wallis test. The population average and range of the normal prostate size were 4.3 ± 0.5 cm (mean ± SD) and 2.9– 5.5 cm, respectively. The population average of mean and maximum CT densities was 36.0 ± 5.1 HU (range 23–57) and 91.7 ± 20.1 HU (range 62–211), respectively. The population average of mean and maximum SUV was 1.3 ± 0.4 (range 0.1–2.7) and 1.6 ± 0.4 (range 1.1– 3.7), respectively. Mean SUV tended to decrease as the prostate size increased (r = −0.16, P = 0.058). Higher mean HU was correlated with higher mean SUV (r = 0.18, P = 0.033). The strongest association was observed between age and prostate size. The prostate gets larger as age increases (r = 0.32, P < 0.001). Prostate mean SUV, max SUV, mean HU, and max HU were not significantly different among different types of primary cancers. Although the normal prostate size increases with age, it does not significantly affect the gland’s metabolism and CT density, and therefore age–correction of these parameters may be unnecessary.
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DOI：
10.1016/s1095-0397(99)00014-x
发表时间：
1999-05-01
期刊：
Clinical positron imaging : official journal of the Institute for Clinical P.E.T
影响因子：
--
作者：
Jadvar, Hossein;Fischman, Alan J.
通讯作者：
Fischman, Alan J.
影响因子：
3.1
作者：
Oyama, Nobuyuki;Akino, Hironobu;Okada, Kenichiro
通讯作者：
Okada, Kenichiro
影响因子：
2.4
作者：
Oyama, N;Akino, H;Okada, K
通讯作者：
Okada, K
影响因子：
19.7
作者：
Shreve, PD;Grossman, HB;Wahl, RL
通讯作者：
Wahl, RL
影响因子：
3.1
作者：
Conti, PS;Lilien, DL;Bading, JR
通讯作者：
Bading, JR