Involvement of human left dorsolateral prefrontal cortex in perceptual decision making is independent of response modality.
Involvement of human left dorsolateral prefrontal cortex in perceptual decision making is independent of response modality.
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DOI：
10.1073/pnas.0603949103
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发表时间：
2006-06-27
影响因子：
11.1
通讯作者：
Ungerleider LG
中科院分区：
文献类型：
--
作者：
Heekeren HR;Marrett S;Ruff DA;Bandettini PA;Ungerleider LG
感知决策通常需要处理感觉信号，形成决策，以及规划和执行运动反应。尽管最近对猴子和人类的研究揭示了知觉决策的可能神经机制，但对决策如何随后转化为运动动作以及决策是否在抽象层面上表示，即，独立于特定的运动反应。为了解决这个问题，我们使用功能性磁共振成像来监测大脑活动的变化，而人类受试者在随机点视觉刺激中辨别运动的方向，这些视觉刺激在连贯性上各不相同，并以按下按钮或扫视眼球运动做出反应。我们假设代表决策变量的区域对高相干刺激的反应比对低相干刺激的反应要大，而与用于表达决策的运动系统无关。四个领域被发现，满足这一条件：左后背外侧前额叶皮质（DLPFC），左后扣带回皮质，左顶下小叶，左梭状回/海马旁回。我们以前发现，当受试者作出明确的决定，降级的脸和房子的刺激，左后DLPFC表现出更大的反应，高-相对于低相干刺激。此外，左后DLPFC似乎在知觉决策期间执行来自感觉处理区域的信号的比较。这些数据表明，参与知觉决策的左后DLPFC超越了任务和反应的特异性，从而使感官证据，决策和行动之间的灵活联系。
Perceptual decision making typically entails the processing of sensory signals, the formation of a decision, and the planning and execution of a motor response. Although recent studies in monkeys and humans have revealed possible neural mechanisms for perceptual decision making, much less is known about how the decision is subsequently transformed into a motor action and whether or not the decision is represented at an abstract level, i.e., independently of the specific motor response. To address this issue, we used functional MRI to monitor changes in brain activity while human subjects discriminated the direction of motion in random-dot visual stimuli that varied in coherence and responded with either button presses or saccadic eye movements. We hypothesized that areas representing decision variables should respond more to high- than to low-coherence stimuli independent of the motor system used to express a decision. Four areas were found that fulfilled this condition: left posterior dorsolateral prefrontal cortex (DLPFC), left posterior cingulate cortex, left inferior parietal lobule, and left fusifom/parahippocampal gyrus. We previously found that, when subjects made categorical decisions about degraded face and house stimuli, left posterior DLPFC showed a greater response to high- relative to low-coherence stimuli. Furthermore, the left posterior DLPFC appears to perform a comparison of signals from sensory processing areas during perceptual decision making. These data suggest that the involvement of left posterior DLPFC in perceptual decision making transcends both task and response specificity, thereby enabling a flexible link among sensory evidence, decision, and action.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
25
作者：
Calton, JL;Dickinson, AR;Snyder, LH
通讯作者：
Snyder, LH
影响因子：
16.2
作者：
Grinband, J;Hirsch, J;Ferrera, VP
通讯作者：
Ferrera, VP
影响因子：
--
作者：
Pelli, DG
通讯作者：
Pelli, DG
DOI：
10.1073/pnas.90.3.873
发表时间：
1993-02-01
影响因子：
11.1
作者：
PETRIDES, M;ALIVISATOS, B;MEYER, E
通讯作者：
MEYER, E