Defeating Cancers' Adaptive Defensive Strategies Using Thermal Therapies: Examining Cancer's Therapeutic Resistance, Ablative, and Computational Modeling Strategies as a means for Improving Therapeutic Outcome.
Defeating Cancers' Adaptive Defensive Strategies Using Thermal Therapies: Examining Cancer's Therapeutic Resistance, Ablative, and Computational Modeling Strategies as a means for Improving Therapeutic Outcome.
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DOI：
10.1177/1533033818762207
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发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Baust JG
中科院分区：
文献类型：
--
作者：
Baust JM;Rabin Y;Polascik TJ;Santucci KL;Snyder KK;Van Buskirk RG;Baust JG
各种热消融疗法目前用于治疗癌症。这些消融疗法通常用于治愈，其成功率类似于并经常超过“金标准”方法。通过更深入地了解热对癌细胞和宿主组织的影响，包括癌细胞突变的分子机制，癌症治疗的前景可能会得到增强，这使得对治疗产生抗药性。此外，热消融治疗可以受益于用于规划、监测、可视化和教育的计算机硬件和计算工具的最新发展。最近发现的癌细胞对凋亡、自噬和坏死破坏的抗性，现在提供了对癌细胞避免免疫监视破坏的策略的理解。此外，这些发现现在提供了对当今临床竞技场中使用的不同类型的消融疗法的成功以及它们如何直接和间接地克服许多癌症防御策略的深入了解。此外，通过成像实现微创热治疗的方式，其有助于解剖特征重建、热探头的插入引导和热传感器的策略性放置，在有效消融治疗的递送中起着关键作用。讨论的热技术包括射频、微波、高强度聚焦超声、激光和冷冻手术。还讨论了热辅助疗法（药物和热治疗的结合）的发展，它为治疗各种癌症提供了新的、更有效的组合物理和基于分子的方法。最后，先进的计算和规划工具也进行了讨论。本文综述了各种分子适应机制癌症的标志负责治疗阻力，一方面，以及如何各种消融治疗，包括加热和冷冻为基础的策略，克服了许多癌症的防御，另一方面，从而提高了各种癌症的治疗方法的潜力。
Diverse thermal ablative therapies are currently in use for the treatment of cancer. Commonly applied with the intent to cure, these ablative therapies are providing promising success rates similar to and often exceeding “gold standard” approaches. Cancer-curing prospects may be enhanced by deeper understanding of thermal effects on cancer cells and the hosting tissue, including the molecular mechanisms of cancer cell mutations, which enable resistance to therapy. Furthermore, thermal ablative therapies may benefit from recent developments in computer hardware and computation tools for planning, monitoring, visualization, and education. Recent discoveries in cancer cell resistance to destruction by apoptosis, autophagy, and necrosis are now providing an understanding of the strategies used by cancer cells to avoid destruction by immunologic surveillance. Further, these discoveries are now providing insight into the success of the diverse types of ablative therapies utilized in the clinical arena today and into how they directly and indirectly overcome many of the cancers’ defensive strategies. Additionally, the manner in which minimally invasive thermal therapy is enabled by imaging, which facilitates anatomical features reconstruction, insertion guidance of thermal probes, and strategic placement of thermal sensors, plays a critical role in the delivery of effective ablative treatment. The thermal techniques discussed include radiofrequency, microwave, high-intensity focused ultrasound, laser, and cryosurgery. Also discussed is the development of thermal adjunctive therapies—the combination of drug and thermal treatments—which provide new and more effective combinatorial physical and molecular-based approaches for treating various cancers. Finally, advanced computational and planning tools are also discussed. This review lays out the various molecular adaptive mechanisms—the hallmarks of cancer—responsible for therapeutic resistance, on one hand, and how various ablative therapies, including both heating- and freezing-based strategies, overcome many of cancer’s defenses, on the other hand, thereby enhancing the potential for curative approaches for various cancers.
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影响因子：
3.5
作者：
Baissalov, R;Sandison, GA;Rewcastle, JC
通讯作者：
Rewcastle, JC
DOI：
10.1016/j.ajg.2011.07.005
发表时间：
2011-09-01
期刊：
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
影响因子：
--
作者：
Azab, Mohamed;Zaki, Samy;Atia, Faried
通讯作者：
Atia, Faried
影响因子：
78.5
作者：
Chabner, BA;Roberts, TG
通讯作者：
Roberts, TG
影响因子：
4.5
作者：
Caso, Jorge R.;Tsivian, Matvey;Polascik, Thomas J.
通讯作者：
Polascik, Thomas J.
影响因子：
2.7
作者：
Baust, JG;Gage, AA;Van Buskirk, R
通讯作者：
Van Buskirk, R