Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer.
Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer.
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DOI：
10.3390/molecules15053135
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发表时间：
2010-04-29
期刊：
影响因子：
--
通讯作者：
Heyerick A
中科院分区：
文献类型：
--
作者：
Ferreira JF;Luthria DL;Sasaki T;Heyerick A
黄花蒿是目前唯一的商业来源的倍半萜内酯青蒿素。自从青蒿素被发现是青蒿素的活性成分以来，Annua在20世纪70年代早期，数百篇论文集中于青蒿素及其半合成类似物二氢青蒿素、蒿甲醚、蒿乙醚和青蒿琥酯的抗寄生虫作用。青蒿素本身由于与其类似物相比生物利用度差而未在主流临床实践中使用。在过去的十年中，青蒿素类化合物的研究已经扩展到其抗癌特性。虽然青蒿素是传统中草药制剂（茶）中的主要生物活性成分，但也存在于茶中的叶类黄酮已显示出多种生物活性，并可能协同青蒿素对疟疾和癌症的作用。然而，只有少数研究关注黄酮类化合物和青蒿素之间的潜在协同作用。世界卫生组织最近通过决议，支持青蒿素类复方疗法，而不是以前使用的青蒿素类单一疗法，这说明了多成分药物疗法可能优于单一疗法这一重新兴起的想法。在这篇评论中，我们将讨论青蒿素及其半合成类似物如果与类黄酮同时递送，可能会更有效地治疗寄生虫病（如疟疾）和癌症。A.一年生植物叶与CYP 450酶的抑制有关，该酶负责改变体内青蒿素的吸收和代谢，而且还与患有寄生虫病和慢性病的受试者的有益免疫调节活性有关。
Artemisia annua is currently the only commercial source of the sesquiterpene lactone artemisinin. Since artemisinin was discovered as the active component of A. annua in early 1970s, hundreds of papers have focused on the anti-parasitic effects of artemisinin and its semi-synthetic analogs dihydroartemisinin, artemether, arteether, and artesunate. Artemisinin per se has not been used in mainstream clinical practice due to its poor bioavailability when compared to its analogs. In the past decade, the work with artemisinin-based compounds has expanded to their anti-cancer properties. Although artemisinin is a major bioactive component present in the traditional Chinese herbal preparations (tea), leaf flavonoids, also present in the tea, have shown a variety of biological activities and may synergize the effects of artemisinin against malaria and cancer. However, only a few studies have focused on the potential synergistic effects between flavonoids and artemisinin. The resurgent idea that multi-component drug therapy might be better than monotherapy is illustrated by the recent resolution of the World Health Organization to support artemisinin-based combination therapies (ACT), instead of the previously used monotherapy with artemisinins. In this critical review we will discuss the possibility that artemisinin and its semi-synthetic analogs might become more effective to treat parasitic diseases (such as malaria) and cancer if simultaneously delivered with flavonoids. The flavonoids present in A. annua leaves have been linked to suppression of CYP450 enzymes responsible for altering the absorption and metabolism of artemisinin in the body, but also have been linked to a beneficial immunomodulatory activity in subjects afflicted with parasitic and chronic diseases.
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影响因子：
2.1
作者：
Atemnkeng, Magnus A.;Chimanuka, Bantuzeko;Plaizier-Vercammen, Jacqueline
通讯作者：
Plaizier-Vercammen, Jacqueline
影响因子：
2.7
作者：
De Leo, Marinella;Braca, Alessandra;Russo, Alessandra
通讯作者：
Russo, Alessandra
影响因子：
4.5
作者：
Abrahamse, SL;Kloots, WJ;van Amelsvoort, JMM
通讯作者：
van Amelsvoort, JMM
影响因子：
3.4
作者：
Batty, KT;Thu, LTA;Kim, NV
通讯作者：
Kim, NV
影响因子：
7.9
作者：
Bilia, A. R.;de Malgalhaes, P. Melillo;Vincieri, F. F.
通讯作者：
Vincieri, F. F.