Connectivity gradients on tractography data: Pipeline and example applications.

Connectivity gradients on tractography data: Pipeline and example applications.
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Tractography数据的连接梯度:管道和示例应用程序。

DOI:
10.1002/hbm.25623
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发表时间:
2021-12-15
影响因子:
4.8
通讯作者:
Mars RB
Mars RB
中科院分区:
医学2区
文献类型:
--
作者:
Blazquez Freches G;Haak KV;Beckmann CF;Mars RB

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灰质连接可以用它的地形组织来描述,但是这种组织下的白色物质连接的不同作用往往是未知的。在这项研究中,我们提出了一种方法,揭示组织的原则,灰色和白色物质的基础上,白色物质的连通性评估使用扩散磁共振成像(MRI)纤维束成像与频谱嵌入梯度映射。所提出的方法的一个关键特征是它的能力,以投影图像的形式显示回其输入数据的个别连接梯度,允许一个特定的白色物质束的观察到的梯度的贡献进行评估。我们证明了我们提出的管道识别前额叶和枕叶灰质的连接梯度的能力。最后,利用纤维束成像,我们证明,它是可以观察梯度内的白色物质束本身。总而言之,所提出的框架提供了一种通用的方法来评估结构性大脑连接的地形组织和驱动它的解剖特征。在这项工作中,我们引入了一个管道,用于根据灰质和白色物质的重叠连接梯度,根据它们的白色物质连接。然后,我们使用管道来获得连接梯度的前额叶和枕叶皮质以及视辐射。最后,我们将这些梯度反向投影到输入的白色物质上,揭示它们的起源。
Gray matter connectivity can be described in terms of its topographical organization, but the differential role of white matter connections underlying that organization is often unknown. In this study, we propose a method for unveiling principles of organization of both gray and white matter based on white matter connectivity as assessed using diffusion magnetic ressonance imaging (MRI) tractography with spectral embedding gradient mapping. A key feature of the proposed approach is its capacity to project the individual connectivity gradients it reveals back onto its input data in the form of projection images, allowing one to assess the contributions of specific white matter tracts to the observed gradients. We demonstrate the ability of our proposed pipeline to identify connectivity gradients in prefrontal and occipital gray matter. Finally, leveraging the use of tractography, we demonstrate that it is possible to observe gradients within the white matter bundles themselves. Together, the proposed framework presents a generalized way to assess both the topographical organization of structural brain connectivity and the anatomical features driving it. In this work, we introduce a pipeline for deriving overlapping connectivity gradients on gray and white matter, according to their white matter connections. We then use the pipeline to derive connectivity gradients on the prefrontal and occipital cortices as well as the optic radiation. Finally, we backproject these gradients onto the input white matter, revealing their origins.
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