Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging.
Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging.
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DOI：
10.1016/j.neuroimage.2022.119658
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发表时间：
2022-11
期刊：
影响因子：
5.7
通讯作者：
Berry, Anne S.
中科院分区：
文献类型：
--
作者：
Parent, Jourdan H.;Ciampa, Claire J.;Harrison, Theresa M.;Adams, Jenna N.;Zhuang, Kailin;Betts, Matthew J.;Maass, Anne;Winer, Joseph R.;Jagust, William J.;Berry, Anne S.
高度神经质是阿尔茨海默病（AD）的一个危险因素，并与应激反应紊乱有关。蓝斑（LC）-儿茶酚胺系统在感知威胁期间被激活，并且是AD病理生理学发展模型的核心，因为它是发展异常tau的第一个大脑区域。我们在认知正常的老年人（n = 47）中检查了“大5”人格特征、用[18 F]Fluoro-m-tyrosine PET测量的LC儿茶酚胺合成能力和用[18 F]Flortaucipir PET测量的tau负荷之间的关系。使用[11 C]匹兹堡化合物B PET测定β-淀粉样蛋白（Aβ）状态（n = 14例Aβ阳性）。较低的LC儿茶酚胺合成能力与较高的神经质，更多的抑郁症状，老年抑郁量表测量，更高的杏仁核tau-PET结合。与其他人格特质的探索性分析显示，低特质焦虑也与较低的LC儿茶酚胺合成能力，和更多的抑郁症状。一个显着的间接路径连接高神经质和低焦虑，以更大的杏仁核tau蛋白的负担，通过其相互关联与低LC儿茶酚胺合成能力。总之，这些研究结果揭示了LC儿茶酚胺合成能力是一个有前途的标志物的情感健康和病理负担在老龄化，并确定候选人的神经生物学机制的影响，个性对痴呆症的脆弱性增加。
Higher neuroticism is a risk factor for Alzheimer’s disease (AD), and is implicated in disordered stress responses. The locus coeruleus (LC)-catecholamine system is activated during perceived threat and is a centerpiece of developing models of the pathophysiology of AD, as it is the first brain region to develop abnormal tau. We examined relationships among the “Big 5” personality traits, LC catecholamine synthesis capacity measured with [18F]Fluoro-m-tyrosine PET, and tau burden measured with [18F]Flortaucipir PET in cognitively normal older adults (n = 47). β-amyloid (Aβ) status was determined using [11C]Pittsburgh compound B PET (n = 14 Aβ positive). Lower LC catecholamine synthesis capacity was associated with higher neuroticism, more depressive symptoms as measured by the Geriatric Depression Scale, and higher amygdala tau-PET binding. Exploratory analyses with other personality traits revealed that low trait conscientiousness was also related to both lower LC catecholamine synthesis capacity, and more depressive symptoms. A significant indirect path linked both high neuroticism and low conscientiousness to greater amygdala tau burden via their mutual association with low LC catecholamine synthesis capacity. Together, these findings reveal LC catecholamine synthesis capacity to be a promising marker of affective health and pathology burden in aging, and identifies candidate neurobiological mechanisms for the effect of personality on increased vulnerability to dementia.
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影响因子：
10.6
作者：
Aston-Jones, G;Rajkowski, J;Cohen, J
通讯作者：
Cohen, J
影响因子：
7.6
作者：
Ciampa, Claire J.;Parent, Jourdan H.;Berry, Anne S.
通讯作者：
Berry, Anne S.
影响因子：
5.3
作者：
Clewett, David V.;Huang, Ringo;Mather, Mara
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Mather, Mara
焦虑和抑郁症临床观点的性别差异。
影响因子：
7.4
作者：
Altemus M;Sarvaiya N;Neill Epperson C
通讯作者：
Neill Epperson C
影响因子：
5
作者：
Fleming KA;Heintzelman SJ;Bartholow BD
通讯作者：
Bartholow BD