Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury.
Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury.
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DOI：
10.1038/sc.2010.67
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发表时间：
2011-01
期刊：
影响因子：
2.2
通讯作者：
Kitzman, P. H.
中科院分区：
文献类型：
--
作者：
Rabchevsky, A. G.;Patel, S. P.;Duale, H.;Lyttle, T. S.;O'Dell, C. R.;Kitzman, P. H.
利用一个完全横断脊髓损伤（SCI）模型在第四胸椎水平的成年大鼠，我们评估是否阻断伤害性刺激低于损伤减少异常的躯体和自主运动反射，表现在肌肉痉挛和高血压自主神经反射障碍，分别。加巴喷丁（GBP）耐受性良好，目前用于SCI人群的神经性疼痛管理;有证据表明，它可以减少突触前谷氨酸的释放。由于临床证据表明，GBP可以抑制慢性SCI人群的肌肉痉挛，我们假设，防止神经传递的伤害性刺激与GBP消除了一个关键的生理联系，这些独特的，衰弱的SCI引起的继发性损害。尾肌痉挛和平均动脉血压反应有害的躯体和/或内脏刺激的行为评估被用来测试GBP对这些异常反射的影响。列克星敦，肯塔基州我们采用股动脉导管插入术和无线电遥测方法监测完全SCI后数周对有害性结直肠扩张（CRD）反应的血压变化。在SCI后2-3周，急性GBP施用（50 mg/kg，i. p.）与盐水处理组相比，显著减弱了由伤害性刺激诱导的自主反射障碍和尾部痉挛。这些结果表明，第一次，一个单一的药物干预，GBP，可以有效地减弱肌肉痉挛和自主神经反射障碍的表现在伤害性刺激。
Utilizing a complete transection spinal cord injury (SCI) model at the fourth thoracic vertebral level in adult rats, we evaluated whether blocking noxious stimuli below the injury diminishes abnormal somatic and autonomic motor reflexes, manifested in muscular spasticity and hypertensive autonomic dysreflexia, respectively. Gabapentin (GBP) is well-tolerated and currently used to manage neuropathic pain in the SCI population; evidence suggests it acts to decrease presynaptic glutamate release. Since clinical evidence indicates that GBP may suppress muscular spasticity in the chronic SCI population, we hypothesized that preventing neurotransmission of noxious stimuli with GBP eliminates a critical physiological link to these distinct, debilitating SCI-induced secondary impairments. Behavioural assessments of tail muscle spasticity and mean arterial blood pressure responses to noxious somatic and/or visceral stimulation were used to test the effects of GBP on these abnormal reflexes. Lexington, Kentucky We employed femoral artery catheterization and radio-telemetric approaches to monitor blood pressure alterations in response to noxious colorectal distension (CRD) weeks after complete SCI. At 2-3 weeks post-SCI, acute GBP administration (50 mg/kg, i.p.) significantly attenuated both autonomic dysreflexia and tail spasticity induced by noxious stimuli compared to saline-treated cohorts. These results demonstrate, for the first time, that a single pharmacological intervention, GBP, can effectively attenuate the manifestation of both muscular spasticity and autonomic dysreflexia in response to noxious stimuli.
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影响因子：
5.3
作者：
Cameron, AA;Smith, GM;Rabchevsky, AG
通讯作者：
Rabchevsky, AG
DOI：
10.1152/ajpheart.1995.268.5.h2077
发表时间：
1995-05-01
影响因子：
4.8
作者：
KRASSIOUKOV, AV;WEAVER, LC
通讯作者：
WEAVER, LC
DOI：
10.1152/ajpheart.1997.272.2.h625
发表时间：
1997-02-01
影响因子：
4.8
作者：
Maiorov, DN;Weaver, LC;Krassioukov, AV
通讯作者：
Krassioukov, AV
影响因子：
3.3
作者：
Kitzman, P. H.;Uhl, T. L.;Dwyer, M. K.
通讯作者：
Dwyer, M. K.
影响因子：
5.3
作者：
Kitzman, P
通讯作者：
Kitzman, P