AT1R gene rs389566 polymorphism contributes to MACCEs in hypertension patients.
AT1R gene rs389566 polymorphism contributes to MACCEs in hypertension patients.
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DOI：
10.1186/s12872-023-03223-w
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发表时间：
2023-06-03
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
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作者：
目的探讨血管紧张素转换酶1R(AT1R)基因多态性与新疆地区高血压合并冠心病(CAD)患者主要不良心脑血管事件(MACCEs)的关系。374名冠心病患者和341名非冠心病患者作为研究参与者，他们都有高血压诊断。采用单核苷酸多态性扫描™分型方法对AT1R基因多态性进行分型。在门诊或电话访谈中，记录MACCEs。采用Kaplan-Meier曲线和Cox生存分析探讨AT1R基因多态性与MACCEs发生的关系。AT1R基因rs389566与MACCEs相关。AT1R基因TT型Rs389566的MACCEs发生率显著高于AA + AT型(75.2%vs.24.8%，P = 0.033)。高龄(OR = 1.028，95%CI：1.009~1.0047，P = 0.003)和rs389566的TT基因型(OR = 1.770，95%CI：1.148~2.729，P = 0.01)是MACCEs的危险因素。AT1R基因rs389566 TT型可能是高血压患者发生MACCEs的易感因素。同时应重视高血压合并冠心病患者MACCEs的预防。尤其是携带AT1R rs389566 TT型的老年高血压患者，需要避免不良的生活方式，加强血压控制，减少MACCEs的发生。
To investigate the possible association between AT1R gene polymorphisms and major adverse cardiovascular and cerebrovascular events (MACCEs) in hypertension patients combined with or without coronary artery disease (CAD) in Xinjiang. 374 CAD patients and 341 non-CAD individuals were enrolled as study participants and all of them have a hypertension diagnosis. AT1R gene polymorphisms were genotyped by SNPscan™ typing assays. During the follow-up in the clinic or by telephone interview, MACCEs were recorded. Kaplan–Meier curves and Cox survival analyses were used to explore the association between AT1R gene polymorphisms and the occurrence of MACCEs. AT1R gene rs389566 was associated with MACCEs. The TT genotype of the AT1R gene rs389566 had a significantly higher probability of MACCEs than the AA + AT genotype (75.2% vs. 24.8%, P = 0.033). Older age (OR = 1.028, 95% CI: 1.009–1.0047, P = 0.003) and TT genotype of rs389566 (OR = 1.770, 95% CI: 1.148–2.729, P = 0.01) were risk factors of MACCEs. AT1R gene rs389566 TT genotype may be a predisposing factor for the occurrence of MACCEs in hypertensive patients. We should also pay more attention to the prevent of MACCEs in hypertension patients combined with CAD. Especially those elderly hypertensive patients carrying AT1R rs389566 TT genotype requires avoidance of unhealthy lifestyle, better management of blood pressure control and reduce the occurrence of MACCEs.
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DOI：
10.1007/s12471-018-1134-0
发表时间：
2018-09
期刊：
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
影响因子：
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作者：
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发表时间：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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