Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulation.
Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulation.
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DOI：
10.1016/j.pnpbp.2011.05.015
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发表时间：
2011-08-15
影响因子：
5.6
通讯作者：
Lukas, Scott E.
中科院分区：
文献类型：
--
作者：
Licata, Stephanie C.;Lowen, Steven B.;Trksak, George H.;MacLean, Robert R.;Lukas, Scott E.
唑吡坦是一种短效咪唑并吡啶类催眠药，与特定GABAA受体上的苯二氮卓类结合位点结合，以增强快速抑制性神经传递。唑吡坦的行为和受体药理学已被广泛研究，但对其体内神经元底物知之甚少。在本受试者内、双盲和安慰剂对照研究中，使用3 T血氧水平依赖性功能性磁共振成像（BOLD fMRI）评估唑吡坦在脑内的作用。健康受试者（n=12）在急性口服唑吡坦（0、5、10或20 mg）后60分钟进行扫描，并在呈现闪烁棋盘时测量视觉皮层中BOLD信号的变化。在整个过程中持续监测心率和血氧饱和度。唑吡坦（10和20 mg）降低了由该刺激产生的强大视觉系统激活，但对fMRI扫描期间的生理活动没有影响。唑吡坦对视觉皮层内BOLD信号的调节与位于该区域的GABAA受体的丰富分布一致，以及先前的研究表明GABA介导的神经元抑制增加与BOLD激活减少之间的关系。
Zolpidem is a short-acting imidazopyridine hypnotic that binds at the benzodiazepine binding site on specific GABAA receptors to enhance fast inhibitory neurotransmission. The behavioral and receptor pharmacology of zolpidem has been studied extensively, but little is known about its neuronal substrates in vivo. In the present within-subject, double-blind, and placebo-controlled study, blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) at 3 Tesla was used to assess the effects of zolpidem within the brain. Healthy participants (n=12) were scanned 60 minutes after acute oral administration of zolpidem (0, 5, 10, or 20 mg), and changes in BOLD signal were measured in the visual cortex during presentation of a flashing checkerboard. Heart rate and oxygen saturation were monitored continuously throughout the session. Zolpidem (10 and 20 mg) reduced the robust visual system activation produced by presentation of this stimulus, but had no effects on physiological activity during the fMRI scan. Zolpidem’s modulation of the BOLD signal within the visual cortex is consistent with the abundant distribution of GABAA receptors localized in this region, as well as previous studies showing a relationship between increased GABA-mediated neuronal inhibition and a reduction in BOLD activation.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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发表时间：
1998-07-01
影响因子：
6.3
作者：
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