Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH.
Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH.
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DOI：
10.1016/j.celrep.2021.108992
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发表时间：
2021-04-20
期刊：
影响因子：
8.8
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Wang M;An Y;Gao L;Dong S;Zhou X;Feng Y;Wang P;Dimopoulos G;Tang H;Wang J
植物花蜜来源的糖是蚊子的主要能量来源，但其对疟原虫媒介能力的影响仍不清楚。在这里，我们发现史氏按蚊的伯氏疟原虫感染会导致整体代谢组的变化，其中对葡萄糖代谢的影响最显着。以葡萄糖或海藻糖（主要的血淋巴糖）为食，使蚊子中肠碱化，从而使蚊子更容易受到疟原虫感染。葡萄糖/海藻糖饮食促进共生细菌 Asaia bogorensis 的增殖，这种细菌以增加中肠 pH 值的方式重塑葡萄糖代谢，从而促进疟原虫配子发生。我们还证明，来自不同天然植物花蜜的糖成分会影响博格曲霉的生长，从而使疟原虫更加容易生长。总而言之，我们的结果表明，膳食葡萄糖是疟原虫蚊媒能力的重要决定因素，进一步强调了蚊子与微生物群相互作用在调节疟原虫发育中的关键作用。王等人。研究表明，补充葡萄糖/海藻糖可促进调节葡萄糖代谢的共生细菌 Asaia 的扩增，从而导致蚊子中肠 pH 值升高。 pH值的增加促进伯氏疟原虫的性发育。
Plant-nectar-derived sugar is the major energy source for mosquitoes, but its influence on vector competence for malaria parasites remains unclear. Here, we show that Plasmodium berghei infection of Anopheles stephensi results in global metabolome changes, with the most significant impact on glucose metabolism. Feeding on glucose or trehalose (the main hemolymph sugars) renders the mosquito more susceptible to Plasmodium infection by alkalizing the mosquito midgut. The glucose/trehalose diets promote proliferation of a commensal bacterium, Asaia bogorensis, that remodels glucose metabolism in a way that increases midgut pH, thereby promoting Plasmodium gametogenesis. We also demonstrate that the sugar composition from different natural plant nectars influences A. bogorensis growth, resulting in a greater permissiveness to Plasmodium. Altogether, our results demonstrate that dietary glucose is an important determinant of mosquito vector competency for Plasmodium, further highlighting a key role for mosquito-microbiota interactions in regulating the development of the malaria parasite. Wang et al. show that glucose/trehalose supplementation promotes the expansion of a commensal bacterium Asaia that modulates glucose metabolism, resulting in an increase of mosquito midgut pH. The pH increase promotes Plasmodium berghei sexual development.
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影响因子：
5.3
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