Exploring Comorbidities in Adolescent and Young Adults with Hypermobile Ehlers-Danlos Syndrome with and without a Surgical History: A Preliminary Investigation.
Exploring Comorbidities in Adolescent and Young Adults with Hypermobile Ehlers-Danlos Syndrome with and without a Surgical History: A Preliminary Investigation.
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DOI：
10.3390/children10091562
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发表时间：
2023-09-16
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影响因子：
--
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文献类型：
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埃勒斯-当洛斯综合征 (EDS) 是一种影响皮肤、关节、脉管系统和内脏器官的罕见疾病。大约 85% 的受影响者被归类为过度活动型 (hEDS)，这与许多医学和精神合并症有关，包括慢性疼痛。此外，大约 71% 的 hEDS 患者至少接受过一次外科手术；然而，人们对手术指标和术后疼痛结果知之甚少。这项初步研究使用医学图表审查来确定一组患有 hEDS 和有手术史的青少年和年轻患者与没有手术史的患者相比，合并症的频率和性质。结果显示，被诊断患有 hEDS 并接受手术的患者比未接受手术的患者报告的合并症（例如 CRPS、IBS、纤维肌痛、POTS、甲状腺功能减退症等）明显更多。 70% 接受手术的患者属于骨科、胃肠道或腹腔镜/子宫内膜异位症相关手术类别。识别有需要手术风险的 hEDS 患者将有助于确定导致手术结果不佳的风险因素的机制。这项研究的结果可能对接受手术的 hEDS 患者的管理和护理具有指导意义。
Ehlers–Danlos Syndrome (EDS) is a rare disease affecting the skin, joints, vasculature, and internal organs. Approximately 85% of those affected are categorized as the hypermobile type (hEDS), which is associated with numerous medical and psychiatric comorbidities, including chronic pain. Additionally, approximately 71% of patients with hEDS undergo at least one surgical procedure; however, indicators for surgery and pain outcomes after surgery are poorly understood. This preliminary study used a medical chart review to identify the frequency and nature of comorbidities in a cohort of adolescents and young adult patients with hEDS and a surgical history compared to those without a surgical history. Results showed that patients diagnosed with hEDS who underwent surgery reported significantly more comorbidities (e.g., CRPS, IBS, Fibromyalgia, POTS, hypothyroidism, etc.) than those who did not have surgery. Seventy percent of individuals who presented for surgery fell within the categories of orthopedic, gastrointestinal, or laparoscopic/endometriosis-related surgeries. Identifying patients with hEDS who are at risk for needing surgery will help identify the mechanisms contributing to risk factors for poor surgical outcomes. The results of this study may be instructive in the management and care of hEDS patients undergoing surgery.
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