A systematic review of the association between perinatal depression and cognitive development in infancy in low and middle-income countries.

A systematic review of the association between perinatal depression and cognitive development in infancy in low and middle-income countries.
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DOI:
10.1371/journal.pone.0253790
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发表时间:
2021
期刊:
影响因子:
3.7
通讯作者:
Sharp H
Sharp H
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Bluett-Duncan M;Kishore MT;Patil DM;Satyanarayana VA;Sharp H

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围产期抑郁症和婴儿认知发育之间的关联已经在高收入背景下的研究中得到了很好的证明,但关于低收入和中等收入国家(LMICs)相同关系的文献却不太发达。本研究的目的是系统地回顾这一领域的已知知识,以便为中低收入国家的早期干预和未来研究提供信息。在Prospero(CRD 42018108589)上预先注册了审查方案,并使用一致的关键词集检索了相关电子数据库,根据合格性标准筛选了1473篇文章。16篇文章被纳入综述,7篇集中在产前阶段,8篇集中在产后阶段,1篇包括两者。八项研究中有五项发现产前抑郁症(d = 0.21 - 0.93)与婴儿认知发展之间存在显著关联,而九项研究中有四项发现产后抑郁症(d = 0.17 - 0.47)与婴儿认知发展之间存在显著关联。尽管有证据表明,中低收入国家应优先考虑产前心理健康护理,但许多研究并没有充分隔离抑郁症在每个时期的影响。此外,很少有研究探讨围产期抑郁症和其他相关因素之间可能存在的更复杂的相互作用。在当前理论的推动下,需要在LMIC环境中进行更多高质量的研究,以测试主效应并检查认知发展的调节或中介途径。
The association between perinatal depression and infant cognitive development has been well documented in research based in high-income contexts, but the literature regarding the same relationship in low and middle-income countries (LMICs) is less developed. The aim of this study is to systematically review what is known in this area in order to inform priorities for early intervention and future research in LMICs. The review protocol was pre-registered on Prospero (CRD42018108589) and relevant electronic databases were searched using a consistent set of keywords and 1473 articles were screened against the eligibility criteria. Sixteen articles were included in the review, seven focusing on the antenatal period, eight on the postnatal period, and one which included both. Five out of eight studies found a significant association between antenatal depression (d = .21-.93) and infant cognitive development, while four out of nine studies found a significant association with postnatal depression (d = .17-.47). Although the evidence suggests that LMICs should prioritise antenatal mental health care, many of the studies did not adequately isolate the effects of depression in each period. Furthermore, very few studies explored more complex interactions that may exist between perinatal depression and other relevant factors. More high-quality studies are needed in LMIC settings, driven by current theory, that test main effects and examine moderating or mediating pathways to cognitive development.
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