NG2 cells (polydendrocytes) in brain physiology and repair.
NG2 cells (polydendrocytes) in brain physiology and repair.
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DOI：
10.3389/fnins.2014.00133
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发表时间：
2014
影响因子：
4.3
通讯作者：
Zhu X
中科院分区：
文献类型：
--
作者：
Nishiyama A;Suzuki R;Zhu X
NG2细胞，也称为少突胶质细胞前体细胞（OPC）或多突胶质细胞，代表与成熟星形胶质细胞、少突胶质细胞、小胶质细胞和神经干细胞不同的主要驻留神经胶质细胞群，并且存在于发育和成熟中枢神经系统（CNS）的整个灰质和白色物质中。虽然它们最确定的命运是少突胶质细胞，但它们以年龄和区域特异性的方式保留谱系可塑性。在发育过程中，它们贡献了腹侧前脑中36%的原生质星形胶质细胞。尽管对NG2细胞的神经元命运进行了深入研究，但没有明确的证据表明它们对神经元群体有实质性贡献。NG2细胞的属性表明它们具有产生少突胶质细胞以外的功能，但它们在神经网络中的确切作用仍然未知。在病理状态下，NG2细胞不仅有助于髓鞘修复，而且它们响应于各种各样的损伤而被激活，并且可以在发病机制中发挥主要作用。
NG2 cells, also referred to as oligodendrocyte precursor cells (OPCs) or polydendrocytes, represent a major resident glial cell population that is distinct from mature astrocytes, oligodendrocytes, microglia, and neural stem cells and exist throughout the gray and white matter of the developing and mature central nervous system (CNS). While their most established fate is the oligodendrocyte, they retain lineage plasticity in an age- and region-specific manner. During development, they contribute to 36% of protoplasmic astrocytes in the ventral forebrain. Despite intense investigation on the neuronal fate of NG2 cells, there is no definitive evidence that they contribute substantially to the neuronal population. NG2 cells have attributes that suggest that they have functions other than to generate oligodendrocytes, but their exact role in the neural network remains unknown. Under pathological states, NG2 cells not only contribute to myelin repair, but they become activated in response to a wide variety of insults and could play a primary role in pathogenesis.
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影响因子：
3.7
作者：
Haberlandt C;Derouiche A;Wyczynski A;Haseleu J;Pohle J;Karram K;Trotter J;Seifert G;Frotscher M;Steinhäuser C;Jabs R
通讯作者：
Jabs R
影响因子：
25
作者：
Etxeberria A;Mangin JM;Aguirre A;Gallo V
通讯作者：
Gallo V
影响因子：
64.8
作者：
Bergles, DE;Roberts, JDB;Jahr, CE
通讯作者：
Jahr, CE
影响因子：
--
作者：
Gonzalez-Perez O;Alvarez-Buylla A
通讯作者：
Alvarez-Buylla A
影响因子：
56.9
作者：
Ge, Woo-Ping;Yang, Xiu-Juan;Duan, Shumin
通讯作者：
Duan, Shumin