Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor.
Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor.
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DOI：
10.1016/j.brainresrev.2011.01.001
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发表时间：
2011-06-24
影响因子：
--
通讯作者：
Alvarez-Buylla A
中科院分区：
文献类型：
--
作者：
Gonzalez-Perez O;Alvarez-Buylla A
脱髓鞘疾病的特征是轴鞘上少突胶质细胞和髓鞘的广泛损失。这些神经系统疾病是年轻人致残的常见原因，但到目前为止，还没有有效的治疗方法。神经干细胞（neural stem cells, NSCs）可能在脑修复治疗中发挥重要作用。成人心室下区（SVZ）的NSCs，也被称为b型细胞，是一种多电位细胞，可以自我更新并产生神经元和胶质细胞。最近的研究表明，SVZ型b细胞衍生的细胞对表皮生长因子（EGF）刺激具有积极反应，具有高度迁移和增殖能力。有趣的是，这些egf激活的细胞亚群表达少突胶质前体细胞（OPCs）的标记物。当EGF被去除后，svz衍生的OPCs在胼胝体、穹状膜和纹状体的白质束中分化为髓鞘鞘和髓鞘鞘前少突胶质细胞。在脱髓鞘病变存在的情况下，来自egf刺激的SVZ祖细胞的OPCs有助于髓磷脂修复。鉴于其高迁移潜力和分化成髓鞘形成细胞的能力，SVZ NSCs是保存白质中少突胶质细胞群和修复脱髓鞘损伤的重要内源性OPCs来源。
Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma. These neurological disorders are a common cause of disability in young adults, but so far, there is no effective treatment against them. It has been suggested that neural stem cells (NSCs) may play an important role in brain repair therapies. NSCs in the adult subventricular zone (SVZ), also known as Type-B cells, are multipotential cells that can self-renew and give rise to neurons and glia. Recent findings have shown that cells derived from SVZ Type-B cells actively respond to epidermal-growth-factor (EGF) stimulation becoming highly migratory and proliferative. Interestingly, a subpopulation of these EGF-activated cells expresses markers of oligodendrocyte precursor cells (OPCs). When EGF administration is removed, SVZ-derived OPCs differentiate into myelinating and pre-myelinating oligodendrocytes in the white matter tracts of corpus callosum, fimbria fornix and striatum. In the presence of a demyelinating lesion, OPCs derived from EGF-stimulated SVZ progenitors contribute to myelin repair. Given their high migratory potential and their ability to differentiate into myelin-forming cells, SVZ NSCs represent an important endogenous source of OPCs for preserving the oligodendrocyte population in the white matter and for the repair of demyelinating injuries.
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影响因子：
--
作者：
Bergles DE;Jabs R;Steinhäuser C
通讯作者：
Steinhäuser C
影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
25
作者：
Etxeberria A;Mangin JM;Aguirre A;Gallo V
通讯作者：
Gallo V
DOI：
10.1007/bf03206631
发表时间：
2004-10-01
期刊：
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Barker, Roger A;Widner, Hakan
通讯作者：
Widner, Hakan
影响因子：
4.7
作者：
Cate, Holly S.;Sabo, Jennifer K.;Kilpatrick, Trevor J.
通讯作者：
Kilpatrick, Trevor J.