Developmental lead exposure induces tactile defensiveness in rhesus monkeys (Macaca mulatta).
Developmental lead exposure induces tactile defensiveness in rhesus monkeys (Macaca mulatta).
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DOI：
10.1289/ehp.11203
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发表时间：
2008-10
影响因子：
10.4
通讯作者：
Schneider ML
中科院分区：
文献类型：
--
作者：
Moore CF;Gajewski LL;Laughlin NK;Luck ML;Larson JA;Schneider ML
儿童的触觉防御与困难的社会关系、情绪失调和注意力不集中有关。然而，尽管铅暴露也与注意力不集中和情绪失调有关，但目前还没有针对儿童或动物的铅暴露和触觉防御的研究。在这项研究中，我们测试了铅暴露是否会引起恒河猴的触觉防御。我们对 61 只猴子进行了 3（无铅、1 年铅、2 年铅）× 2（琥珀酸螯合或无）析因实验，测试了 4 岁时的触觉防御能力。接受铅治疗的猴子从出生 8 天到 1 岁或 2 岁期间每天口服含铅的牛奶溶液，使血铅水平达到 35-40 mg/dL。 1岁时进行琥珀酸螯合疗法或安慰剂。我们通过对三种纹理中的每一种进行六次重复试验来测量触觉防御性，即轻扫脸颊和颈部。与对照组相比，接触铅的猴子对重复的触觉刺激表现出更高的负面反应。生命前 3 个月的血铅与触觉防御测试的阴性反应呈正相关。铅暴露×琥珀酸螯合×试验之间存在相互作用，但尚不清楚琥珀酸螯合对于触觉防御是否有益。这是第一份暗示铅是触觉防御的潜在原因的报告。研究应该检查铅暴露是否与儿童的触觉防御有关。
Tactile defensiveness in children is associated with difficult social relations, emotional dysregulation, and inattention. However, there are no studies of lead exposure and tactile defensiveness in children or animals in spite of the fact that lead exposure is also associated with inattention and emotional dysregulation. In this study we tested whether lead exposure induces tactile defensiveness in rhesus monkeys. We tested 61 monkeys from a 3 (no lead, 1-year lead, 2-year lead) × 2 (succimer chelation or not) factorial experiment for tactile defensiveness at 4 years of age. Lead-treated monkeys had been orally administered lead in a daily milk solution from 8 days of life to either 1 or 2 years of age to produce blood lead levels of 35–40 mg/dL. Succimer chelation therapy or placebo was administered at 1 year of age. We measured tactile defensiveness using six repeated trials of each of three textures as a swipe to the cheek and neck. Lead-exposed monkeys showed higher negative responses to repeated tactile stimulation compared with controls. Blood lead during the first 3 months of life was positively correlated with the negative response on the tactile defensiveness test. There was an interaction of lead exposure × succimer chelation × trials, but it is not clear that succimer chelation was beneficial with respect to tactile defensiveness. This is the first report to implicate lead as a potential cause of tactile defensiveness. Research should examine whether lead exposure is associated with tactile defensiveness in children.
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影响因子：
9.8
作者：
Chuang, Hung-Yi;Kuo, Ching-Hsia;Wu, Trong-Neng
通讯作者：
Wu, Trong-Neng
影响因子：
3.9
作者：
BARANEK, GT;BERKSON, G
通讯作者：
BERKSON, G
影响因子：
56.9
作者：
BUSHNELL, PJ;BOWMAN, RE;MARLAR, RJ
通讯作者：
MARLAR, RJ
影响因子：
2.9
作者：
Ferguson, SA;Felipa, HN;Bowman, RE
通讯作者：
Bowman, RE
美国儿童的环境有毒物质和注意力缺陷多动障碍的暴露。
影响因子：
10.4
作者：
Braun, Joe M;Kahn, Robert S;Froehlich, Tanya;Auinger, Peggy;Lanphear, Bruce P
通讯作者：
Lanphear, Bruce P