An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography.
An intra-neural microstimulation system for ultra-high field magnetic resonance imaging and magnetoencephalography.
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DOI：
10.1016/j.jneumeth.2017.07.016
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发表时间：
2017-10-01
影响因子：
3
通讯作者：
Francis ST
中科院分区：
文献类型：
--
作者：
Glover PM;Watkins RH;O'Neill GC;Ackerley R;Sanchez-Panchuelo R;McGlone F;Brookes MJ;Wessberg J;Francis ST
我们提出了一种用于7 T fMRI和MEG的神经内微刺激系统。这种定制的系统消除了现有设备的问题。它提供了高效的工作流程，提高了参与者的舒适度和安全性。刺激单个机械感受器引起7 T fMRI和MEG的活动。在MEG中首次显示了对单一刺激的反应。神经内微刺激（INMS）是一种允许将低电流电脉冲精确递送到人类外周神经中的技术。单单位INMS可用于在显微神经造影术期间刺激单个传入神经纤维。将其与神经成像相结合，可以对中枢神经系统激活进行独特的监测，以响应单一的受控触觉输入，功能性磁共振成像（fMRI）提供大脑活动的精确空间定位和脑磁图（MEG）的高时间分辨率。适用于电生理学实验室的INMS系统已经存在多年。我们描述了一个INMS系统，专门设计用于提供超高场（7 T）功能磁共振成像和脑磁图的兼容性。解决了许多技术和安全问题。该系统是完全模拟的，允许任意频率和振幅的INMS刺激。在MRI和MEG屏蔽室环境中获得的单一记录与在“清洁”电生理记录环境中获得的记录相当。单个机械感受性传入神经的单位INMS（电流<7 μA，200 μs脉冲）在fMRI和MEG中产生适当和稳健的反应。这种定制的MRI和MEG兼容刺激器克服了现有INMS方法的问题;它允许在记录和刺激模式之间进行良好控制的切换，防止由于长电缆长度而造成的电击，允许无限的刺激模式，并提供具有改进的工作流程和参与者舒适度的系统。我们证明，可以与fMRI和MEG成像系统一起使用的INMS集成系统的要求已完全满足。
We propose an intra-neural microstimulation system for 7 T fMRI and MEG. This custom-built system removes issues with existing equipment. It provides efficient work-flow and improved participant comfort and safety. Stimulating single mechanoreceptors evokes activity in 7 T fMRI and MEG. Responses to unitary stimulation are shown for the first time in MEG. Intra-neural microstimulation (INMS) is a technique that allows the precise delivery of low-current electrical pulses into human peripheral nerves. Single unit INMS can be used to stimulate individual afferent nerve fibres during microneurography. Combining this with neuroimaging allows the unique monitoring of central nervous system activation in response to unitary, controlled tactile input, with functional magnetic resonance imaging (fMRI) providing exquisite spatial localisation of brain activity and magnetoencephalography (MEG) high temporal resolution. INMS systems suitable for use within electrophysiology laboratories have been available for many years. We describe an INMS system specifically designed to provide compatibility with both ultra-high field (7 T) fMRI and MEG. Numerous technical and safety issues are addressed. The system is fully analogue, allowing for arbitrary frequency and amplitude INMS stimulation. Unitary recordings obtained within both the MRI and MEG screened-room environments are comparable with those obtained in ‘clean’ electrophysiology recording environments. Single unit INMS (current <7 μA, 200 μs pulses) of individual mechanoreceptive afferents produces appropriate and robust responses during fMRI and MEG. This custom-built MRI- and MEG-compatible stimulator overcomes issues with existing INMS approaches; it allows well-controlled switching between recording and stimulus mode, prevents electrical shocks because of long cable lengths, permits unlimited patterns of stimulation, and provides a system with improved work-flow and participant comfort. We demonstrate that the requirements for an INMS-integrated system, which can be used with both fMRI and MEG imaging systems, have been fully met.
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影响因子：
14.5
作者：
TOREBJORK, HE;VALLBO, AB;OCHOA, JL
通讯作者：
OCHOA, JL
影响因子：
2.5
作者：
Ochoa JL
通讯作者：
Ochoa JL
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2.5
作者：
Kelly, EF;Trulsson, M;Folger, SE
通讯作者：
Folger, SE
影响因子：
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作者：
Liuzzi, Lucrezia;Gascoyne, Lauren E.;Brookes, Matthew J.
通讯作者：
Brookes, Matthew J.
影响因子：
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作者：
Meyer, Sofie S.;Bonaiuto, James;Barnes, Gareth R.
通讯作者：
Barnes, Gareth R.