Inhibition of adult neurogenesis reduces avoidance behavior in male, but not female, mice subjected to early life adversity.
Inhibition of adult neurogenesis reduces avoidance behavior in male, but not female, mice subjected to early life adversity.
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DOI：
10.1016/j.ynstr.2022.100436
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发表时间：
2022-03
影响因子：
5
通讯作者：
Gould E
中科院分区：
文献类型：
--
作者：
Waters RC;Worth HM;Vasquez B;Gould E
早期生活逆境（ELA）会增加患神经精神疾病（如焦虑症）的风险。然而，将这些负面的早期生活经历与后来的生活疾病联系起来的机制仍不清楚。在啮齿类动物中，可塑性机制，特别是腹侧海马的成年神经发生，已被证明被ELA改变，并且对于缓冲有害的应激诱导结果很重要。目前的研究旨在探讨成人神经发生是否有助于ela诱导的回避行为的改变。使用GFAP-TK转基因模型（允许抑制成年神经发生）和CD1窝鼠对照，我们对小鼠进行了母鼠分离和早期断奶（MSEW）或对照饲养的ELA模式。我们发现完整的成年神经发生小鼠对MSEW的反应没有行为改变。然而，在减少成年神经发生后，先前接受MSEW的雄性小鼠的回避行为出乎意料地减少。在雌性小鼠中没有观察到这一发现，这表明成年出生的神经元在缓冲ela诱导的行为变化方面存在性别差异。结合现有关于ELA和回避行为的文献，本研究表明ELA易感性存在应变差异，成人出生的神经元可能在调节适应行为中发挥作用。
Early life adversity (ELA) increases the risk of developing neuropsychiatric illnesses such as anxiety disorders. However, the mechanisms connecting these negative early life experiences to illness later in life remain unclear. In rodents, plasticity mechanisms, specifically adult neurogenesis in the ventral hippocampus, have been shown to be altered by ELA and important for buffering against detrimental stress-induced outcomes. The current study sought to explore whether adult neurogenesis contributes to ELA-induced changes in avoidance behavior. Using the GFAP-TK transgenic model, which allows for the inhibition of adult neurogenesis, and CD1 littermate controls, we subjected mice to an ELA paradigm of maternal separation and early weaning (MSEW) or control rearing. We found that mice with intact adult neurogenesis showed no behavioral changes in response to MSEW. After reducing adult neurogenesis, however, male mice previously subjected to MSEW had an unexpected decrease in avoidance behavior. This finding was not observed in female mice, suggesting that a sex difference exists in the role of adult-born neurons in buffering against ELA-induced changes in behavior. Taken together with the existing literature on ELA and avoidance behavior, this work suggests that strain differences exist in susceptibility to ELA and that adult-born neurons may play a role in regulating adaptive behavior.
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影响因子：
3.5
作者：
Barha, Cindy K.;Brummelte, Susanne;Galea, Liisa A. M.
通讯作者：
Galea, Liisa A. M.
影响因子：
5.2
作者：
Daskalakis NP;Enthoven L;Schoonheere E;de Kloet ER;Oitzl MS
通讯作者：
Oitzl MS
影响因子：
2.5
作者：
Cui, Minghu;Yang, Ya;Cao, Jun
通讯作者：
Cao, Jun
焦虑和抑郁症临床观点的性别差异。
影响因子：
7.4
作者：
Altemus M;Sarvaiya N;Neill Epperson C
通讯作者：
Neill Epperson C
影响因子：
4.2
作者：
Emmons, Randi;Sadok, Tasneem;Halladay, Lindsay R.
通讯作者：
Halladay, Lindsay R.